2013
Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms
Chen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms. Gene 2013, 531: 23-30. PMID: 23994292, DOI: 10.1016/j.gene.2013.08.047.Peer-Reviewed Original ResearchConceptsProgression of fibrosisFibronectin synthesisChronic kidney diseaseC-Jun NH2-terminal protein kinaseMineralocorticoid hormone aldosteroneKidney fibroblast cell lineTranscription factor c-JunExtracellular signal-regulated kinaseReceptor-dependent activationSignal-regulated kinaseDependent signaling pathwaysKidney injuryInterstitial fibrosisKidney diseaseMineralocorticoid receptorHormone aldosteroneAldosteroneRenal fibroblastsAnimal modelsProtein kinaseFibroblast cell lineFibronectin expressionKidneyFibrosisSubsequent phosphorylation
2008
NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors
Langworthy M, Zhou B, de Caestecker M, Moeckel G, Baldwin HS. NFATc1 Identifies a Population of Proximal Tubule Cell Progenitors. Journal Of The American Society Of Nephrology 2008, 20: 311-321. PMID: 19118153, PMCID: PMC2637056, DOI: 10.1681/asn.2008010094.Peer-Reviewed Original ResearchConceptsProximal tubular cell injuryBALB/c miceAcute kidney injuryTubular cell injuryWild-type miceProximal tubule segmentsKidney injurySerum creatinineCalcineurin inhibitorsC miceSustained injuryNFATc1 activityPTC proliferationCell injuryProximal tubulesNFATc1 expressionSevere injuriesTubule cellsInjuryMercuric chlorideEpithelial regenerationNephron segmentsCyclosporin AMiceTubule segments