2015
Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes
Hassan H, Tian X, Inoue K, Chai N, Liu C, Soda K, Moeckel G, Tufro A, Lee AH, Somlo S, Fedeles S, Ishibe S. Essential Role of X-Box Binding Protein-1 during Endoplasmic Reticulum Stress in Podocytes. Journal Of The American Society Of Nephrology 2015, 27: 1055-1065. PMID: 26303067, PMCID: PMC4814187, DOI: 10.1681/asn.2015020191.Peer-Reviewed Original ResearchConceptsX-box binding protein 1Endoplasmic reticulum stress responseEndoplasmic reticulum stressGlomerular filtration barrierPodocyte injuryReticulum stress responseBinding protein 1Reticulum stressProtein 1Filtration barrierFoot process effacementProgressive albuminuriaMouse modelProcess effacementUnfolded protein response pathwayEpithelial cellsNormal glomerular filtration barrierProtein response pathwayEndoplasmic reticulumPodocytesGenetic inactivationXBP1 pathwayInjuryJNK pathwayStress response
2012
Inorganic Phosphate Stimulates Fibronectin Expression in Renal Fibroblasts
Chen Z, Chen D, McCarthy TL, Centrella M, Zhang Y, Moeckel GW. Inorganic Phosphate Stimulates Fibronectin Expression in Renal Fibroblasts. Cellular Physiology And Biochemistry 2012, 30: 151-159. PMID: 22759963, DOI: 10.1159/000339054.Peer-Reviewed Original Research
2009
Placental Insufficiency Associated with Loss of Cited1 Causes Renal Medullary Dysplasia
Sparrow DB, Boyle SC, Sams RS, Mazuruk B, Zhang L, Moeckel GW, Dunwoodie SL, de Caestecker MP. Placental Insufficiency Associated with Loss of Cited1 Causes Renal Medullary Dysplasia. Journal Of The American Society Of Nephrology 2009, 20: 777-786. PMID: 19297558, PMCID: PMC2663829, DOI: 10.1681/asn.2008050547.Peer-Reviewed Original ResearchConceptsRenal medullary dysplasiaPlacental insufficiencyTissue oxygenationLower urinary tract obstructionUrinary tract obstructionCITED1 expressionIntrauterine growth retardationTract obstructionRenal functionMedullary growthRenal dysplasiaDysplasiaGrowth retardationRenal medullaMutant miceDecreased numberInsufficiencyEarly nephrogenesisNumber of studiesMiceGenetic lossOxygenationUreteric budCircumstantial evidenceInfants
2005
Role of integrin α1β1 in the regulation of renal medullary osmolyte concentration
Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin α1β1 in the regulation of renal medullary osmolyte concentration. American Journal Of Physiology. Renal Physiology 2005, 290: f223-f231. PMID: 16106035, DOI: 10.1152/ajprenal.00371.2004.Peer-Reviewed Original ResearchConceptsIntegrin alpha1-null miceOsmolyte accumulationTonicity enhancer-binding proteinExtracellular matrix receptors integrinsOrganic osmolytesProtective organic osmolytesMEK inhibitor PD 98059Inositol uptakeInhibitor PD 98059Enhancer-binding proteinRenal medullary cellsTubular necrosisGene transcriptionOsmolyte transportersReceptor integrinPD 98059Altered signalingDifferent osmotic conditionsOsmolyte concentrationMammalian kidneyCell behaviorImportant mediatorERK1/2 phosphorylationOsmotic conditionsDuct cells