2005
Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition
Cheng H, Zhang M, Moeckel GW, Zhao Y, Wang S, Qi Z, Breyer MD, Harris RC. Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition. Nephron 2005, 101: e75-e85. PMID: 15995341, DOI: 10.1159/000086645.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConnective Tissue Growth FactorCyclooxygenase 2 InhibitorsFibronectinsGlomerulosclerosis, Focal SegmentalImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsKidneyKidney TubulesMiceMice, Inbred StrainsNephrectomyProteinuriaProto-Oncogene Proteins c-metPyrazolesSulfonamidesTissue DistributionConceptsCyclooxygenase-2 inhibitionROP miceSC58236 treatmentRenal injuryRemnant kidneyImmunoreactive COX-2Immunoreactive TGF-beta1Selective COX-2 inhibitorsSystemic blood pressureConnective tissue growth factorSubtotal renal ablationRenal tubulointerstitial injuryExpression of mediatorsCOX-2 inhibitorsTissue growth factorCollagen IV mRNATubulointerstitial injuryBlood pressureRenal ablationSignificant albuminuriaCOX-2Macrophage markersMouse modelTGF-beta1Remnant group
1997
Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation
Moeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. American Journal Of Physiology 1997, 272: f94-f99. PMID: 9039054, DOI: 10.1152/ajprenal.1997.272.1.f94.Peer-Reviewed Original ResearchConceptsRenal cortexMale Sprague-Dawley ratsSprague-Dawley ratsHepatic arteryRenal arteryRenal synthesisFurosemide diuresisPortal veinOxidase inhibitorsRat kidneyKidneyTotal urineMedullary concentrationUrine samplesMedullaMedullary cellsCortexArteryDe novo synthesisBetaine concentrationsMammalian kidneyWater deprivationDe novoMinNovo synthesis