2019
Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease
Landau SI, Guo X, Velazquez H, Torres R, Olson E, Garcia-Milian R, Moeckel GW, Desir GV, Safirstein R. Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease. Kidney International 2019, 95: 797-814. PMID: 30904067, PMCID: PMC6543531, DOI: 10.1016/j.kint.2018.11.042.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseKidney injuryCisplatin-induced chronic kidney diseaseCisplatin-induced acute kidney injuryToll-like receptor 2Regulated necrosis pathwaysReversible kidney injuryAcute kidney injuryChronic kidney injuryProximal tubular damageKidney injury markersDoses of cisplatinEvidence of fibrosisMechanisms of progressionEffective chemotherapeutic agentWestern blot analysisFirst doseInjury markersIntraperitoneal cisplatinSignificant nephrotoxicityTubular damageKidney functionSecond doseCisplatin administration
2017
Severe Orthostatic Hypotension Complicating Multiple Myeloma
Sury K, Mutter M, Moeckel G, Perazella M. Severe Orthostatic Hypotension Complicating Multiple Myeloma. Journal Of Onco-Nephrology 2017, 1: e8-e12. DOI: 10.5301/jo-n.5000029.Peer-Reviewed Original ResearchRenal replacement therapySevere hemodynamic instabilityVascular amyloidosisMultiple myelomaOrthostatic hypotensionHemodynamic instabilityReplacement therapyContinuous veno-venous hemodialysisSevere orthostatic hypotensionAcute kidney injuryMaximal medical therapyFatal cardiac arrestGlomerular amyloidosisKidney injuryUrinary findingsPersistent symptomsKidney biopsyMedical therapyKidney functionCardiac arrestMultiple fallsRenal amyloidosisTreatment challengesClinical aspectsAmyloidosis
2016
Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial
Kulkarni S, Kirkiles‐Smith N, Deng YH, Formica RN, Moeckel G, Broecker V, Bow L, Tomlin R, Pober JS. Eculizumab Therapy for Chronic Antibody‐Mediated Injury in Kidney Transplant Recipients: A Pilot Randomized Controlled Trial. American Journal Of Transplantation 2016, 17: 682-691. PMID: 27501352, DOI: 10.1111/ajt.14001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAntibodies, Monoclonal, HumanizedChronic DiseaseComplement C5Complement Inactivating AgentsEarly Intervention, EducationalFemaleFollow-Up StudiesGlomerular Filtration RateGraft RejectionGraft SurvivalHumansIsoantibodiesKidney Failure, ChronicKidney Function TestsKidney TransplantationLiving DonorsMaleMiddle AgedPilot ProjectsPrognosisRisk FactorsTissue DonorsTransplant RecipientsYoung AdultConceptsDe novo donor-specific antibodiesComplement inhibitionTreatment groupsNovo donor-specific antibodiesAntibody-Mediated InjuryC1q-positive patientsDonor-specific antibodiesKidney transplant recipientsPrimary end pointEndothelial cell injuryMo of observationEculizumab therapyEculizumab treatmentHumoral injuryTransplant recipientsKidney transplantRenal functionKidney functionChronic settingEGFR trajectoriesTreatment periodCell injuryPatientsEnd pointPercentage change
2013
Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition.
Manjunath V, Moeckel G, Dahl NK. Acute kidney injury in a patient with sarcoidosis: hypercalciuria and hypercalcemia leading to calcium phosphate deposition. Clinical Nephrology 2013, 80: 151-5. PMID: 23845267, DOI: 10.5414/cn107258.Peer-Reviewed Original ResearchConceptsAcute kidney injuryAcute tubular necrosisKidney injuryOH vitamin D levelsVitamin D levelsCalcium oxalate nephrolithiasisRenal functionTubular necrosisKidney biopsyKidney functionCalcium phosphate depositionD levelsGiant cell formationOxalate nephrolithiasisSarcoidosisRandall's plaqueHypercalcemiaHypercalciuriaPatientsInjuryPhosphate depositionPlaquesCell formationCalcium phosphate crystalsDifferent mechanisms
2010
Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic Leukemia
Seo-Mayer P, Kenney B, McNamara J, Stein J, Moeckel GW. Hematuria and Decreased Kidney Function as Initial Signs of Acute B-Cell Lymphoblastic Leukemia. American Journal Of Kidney Diseases 2010, 56: 1001-1005. PMID: 20599308, DOI: 10.1053/j.ajkd.2010.03.029.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaKidney biopsy specimenKidney functionLymphoblastic leukemiaAcute B-cell lymphoblastic leukemiaSmall round blue cellsB-cell lymphoblastic leukemiaInitial presenting signRound blue cellsExtensive retroperitoneal lymphadenopathySignificant nuclear atypiaInduction chemotherapyInitial manifestationRetroperitoneal lymphadenopathyBilateral nephromegalyPresenting signImmunohistochemical workupInterstitial infiltratesBiopsy specimenNuclear atypiaComputed tomographyPositive stainingUnusual caseTerminal deoxynucleotidyl transferaseInitial signs