2009
Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
Aghajanian GK. Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology 2009, 206: 575-585. PMID: 19241062, PMCID: PMC2755104, DOI: 10.1007/s00213-009-1484-9.Peer-Reviewed Original ResearchConceptsAberrant network activityBrain slicesReceptor agonistPyramidal cellsLayer V pyramidal cellsRecent phase II clinical trialPhase II clinical trialGABAA receptor antagonismStandard antipsychotic drugsMGlu2/3 receptor agonistGlutamatergic pyramidal cellsNetwork activityCortical brain slicesDopamine receptor agonistsTreatment of schizophreniaUsual side effectsPrefrontal brain slicesNeuronal network activityInterneuron deficitsGABA interneuronsClinical efficacyLysergic acid diethylamideMetabotropic receptorsReceptor antagonismClinical endpoints
2008
Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy