Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices
Aghajanian GK. Modeling “psychosis” in vitro by inducing disordered neuronal network activity in cortical brain slices. Psychopharmacology 2009, 206: 575-585. PMID: 19241062, PMCID: PMC2755104, DOI: 10.1007/s00213-009-1484-9.Peer-Reviewed Original ResearchConceptsAberrant network activityBrain slicesReceptor agonistPyramidal cellsLayer V pyramidal cellsRecent phase II clinical trialPhase II clinical trialGABAA receptor antagonismStandard antipsychotic drugsMGlu2/3 receptor agonistGlutamatergic pyramidal cellsNetwork activityCortical brain slicesDopamine receptor agonistsTreatment of schizophreniaUsual side effectsPrefrontal brain slicesNeuronal network activityInterneuron deficitsGABA interneuronsClinical efficacyLysergic acid diethylamideMetabotropic receptorsReceptor antagonismClinical endpoints