Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy
Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: Role of corticosterone-mediated apical dendritic atrophy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 359-364. PMID: 18172209, PMCID: PMC2224217, DOI: 10.1073/pnas.0706679105.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsLayer V pyramidal neuronsMedial prefrontal cortexApical dendritic atrophyDendritic atrophyPyramidal neuronsRestraint stressPrefrontal cortexGlucocorticoid receptor antagonist RU486Apical dendritic fieldReceptor antagonist RU486Mild restraint stressWhole-cell recordingsMPFC slicesChronic treatmentStress-induced reductionExcitatory responsesSpine densityApical dendritesPostsynaptic currentsDendritic fieldsExcitatory inputsPyramidal cellsAntagonist RU486Selective atrophy