2013
Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2)
Hou P, Zeng W, Gan G, Lv C, Guo X, Zhang Z, Liu H, Wu Y, Yao J, Wei A, Wang S, Ding J. Inter-α/β subunits coupling mediating pre-inactivation and augmented activation of BKCa(β2). Scientific Reports 2013, 3: 1666. PMID: 23588888, PMCID: PMC3627188, DOI: 10.1038/srep01666.Peer-Reviewed Original Research
2008
Structural Basis for Toxin Resistance of β4-Associated Calcium-activated Potassium (BK) Channels*
Gan G, Yi H, Chen M, Sun L, Li W, Wu Y, Ding J. Structural Basis for Toxin Resistance of β4-Associated Calcium-activated Potassium (BK) Channels*. Journal Of Biological Chemistry 2008, 283: 24177-24184. PMID: 18559348, PMCID: PMC3259794, DOI: 10.1074/jbc.m800179200.Peer-Reviewed Original ResearchConceptsAlpha subunitBeta subunitStructural basisWide open conformationAuxiliary beta subunitsFunctional diversityInternal binding siteToxin resistanceBasic residuesOpen conformationChannel poreSubunitsDiverse interactionsBinding sitesLarge conductancePotassium channelsMSloChannel inhibitorsMutantsDiversityResiduesSitesBetter understandingInteractionLysine-Rich Extracellular Rings Formed by hβ2 Subunits Confer the Outward Rectification of BK Channels
Chen M, Gan G, Wu Y, Wang L, Wu Y, Ding J. Lysine-Rich Extracellular Rings Formed by hβ2 Subunits Confer the Outward Rectification of BK Channels. PLOS ONE 2008, 3: e2114. PMID: 18461166, PMCID: PMC2346552, DOI: 10.1371/journal.pone.0002114.Peer-Reviewed Original ResearchAmino Acid SequenceAnimalsCalciumCharybdotoxinEpitopesLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsLysinePatch-Clamp TechniquesPeptide FragmentsPotassiumProtein SubunitsStatic Electricity