2008
Structural Basis for Toxin Resistance of β4-Associated Calcium-activated Potassium (BK) Channels*
Gan G, Yi H, Chen M, Sun L, Li W, Wu Y, Ding J. Structural Basis for Toxin Resistance of β4-Associated Calcium-activated Potassium (BK) Channels*. Journal Of Biological Chemistry 2008, 283: 24177-24184. PMID: 18559348, PMCID: PMC3259794, DOI: 10.1074/jbc.m800179200.Peer-Reviewed Original ResearchConceptsAlpha subunitBeta subunitStructural basisWide open conformationAuxiliary beta subunitsFunctional diversityInternal binding siteToxin resistanceBasic residuesOpen conformationChannel poreSubunitsDiverse interactionsBinding sitesLarge conductancePotassium channelsMSloChannel inhibitorsMutantsDiversityResiduesSitesBetter understandingInteraction
2007
Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel*
Lv C, Chen M, Gan G, Wang L, Xu T, Ding J. Four-turn α-Helical Segment Prevents Surface Expression of the Auxiliary hβ2 Subunit of BK-type Channel*. Journal Of Biological Chemistry 2007, 283: 2709-2715. PMID: 17991741, DOI: 10.1074/jbc.m704440200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCell LineEndoplasmic ReticulumGene ExpressionHumansLarge-Conductance Calcium-Activated Potassium ChannelsMicroscopy, FluorescenceModels, MolecularMolecular Sequence DataMutagenesis, Site-DirectedPatch-Clamp TechniquesProtein Structure, SecondaryProtein SubunitsRatsRecombinant Fusion ProteinsSequence Homology, Amino AcidConceptsBK-type channelsSurface expressionRat chromaffin cellsExtracellular loopPancreatic beta cellsTrafficking mechanismsN-terminusDRG neuronsHelical segmentsToxin sensitivityBeta cellsClamp techniqueHelp of immunofluorescenceAuxiliary beta subunitsAlpha-helical segmentsChromaffin cellsBeta2 subunitBK channelsHbeta2Retention signalChannel regulatorRegulatory mechanismsBeta subunitEndoplasmic reticulumLarge conductance