Search of a genomic sequence database for potential novel blood group antigens: Investigation into why some amino acid substitutions are not immunogenic
Howe J, Stack G. Search of a genomic sequence database for potential novel blood group antigens: Investigation into why some amino acid substitutions are not immunogenic. Transfusion 2023, 63: 1399-1411. PMID: 37386886, DOI: 10.1111/trf.17459.Peer-Reviewed Original ResearchConceptsBlood group antigensGroup antigensB-cell epitopesGenomic sequence databasesLinear B-cell epitopesLow prevalenceSequence databasesAtypical chemokine receptor 1Chemokine receptor 1New blood group antigensExtracellular domainHuman genome sequence databaseMissense mutationsGenome sequence databaseEpitope prediction programsTransfusion practiceProtein structural analysisPoor immunogenicityAmino acid substitutionsReceptor 1Phenotype prevalenceAntigenStudy designBlood groupPrevalence