Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma
Mittal A, Wang M, Vidyarthi A, Yanez D, Pizzurro G, Thakral D, Tracy E, Colegio OR. Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma. Scientific Reports 2021, 11: 10731. PMID: 34031449, PMCID: PMC8144401, DOI: 10.1038/s41598-021-90200-y.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaSquamous cell carcinomaArginase inhibitionB6 miceCell carcinomaAnti-PD-1 therapeutic efficacyTumor growthArginase inhibitorAnti-PD-1 therapyPD-1 expressionAppropriate tumor modelsCSCC cell linesPre-clinical modelsTumor growth inhibitionNOHA administrationSignificant morbidityC57BL/6 miceImmune microenvironmentImmunocompetent miceCSCC tumorsDeficient miceT cellsMacrophage expressionTherapeutic modalitiesTherapeutic efficacy