1988
Delusional depression and bipolar spectrum: evidence for a possible association from a family study of children.
Weissman M, Warner V, John K, Prusoff B, Merikangas K, Wickramaratne P, Gammon G. Delusional depression and bipolar spectrum: evidence for a possible association from a family study of children. Neuropsychopharmacology 1988, 1: 257-64. PMID: 3251505.Peer-Reviewed Original ResearchConceptsMajor depressionBipolar disorderDelusional depressionBipolar spectrumOffspring of probandsDirect interview studySubgroups of interestNormal controlsPossible associationHealth professionalsDelusional subtypesDepressionDisordersCyclothymiaFamily studiesChildrenSubtypesPedigree studiesThreefold increaseFamily membersPossible relationshipSocial impairmentProbandsFindingsEarlier findings
1986
Depressed Parents and Their Children: General Health, Social, and Psychiatric Problems
Weissman M, John K, Merikangas K, Prusoff B, Wickramaratne P, Gammon G, Angold A, Warner V. Depressed Parents and Their Children: General Health, Social, and Psychiatric Problems. JAMA Pediatrics 1986, 140: 801-805. PMID: 3728409, DOI: 10.1001/archpedi.1986.02140220083038.Peer-Reviewed Original ResearchConceptsMajor depressionPsychiatric disordersDepressed parentsAdverse perinatal eventsMore medical problemsDirect clinical implicationsMore suicide attemptsMore convulsionsPerinatal eventsHead injuryGeneral healthChronic illnessPrevalent disorderPsychiatric problemsClinical implicationsMedical problemsSuicide attemptsSociodemographic backgroundDisordersFurther studiesSignificant differencesDepressionChildrenMore distressDevelopmental landmarks
1984
Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity
Weissman M, Wickramaratne P, Merikangas K, Leckman J, Prusoff B, Caruso K, Kidd K, Gammon G. Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity. JAMA Psychiatry 1984, 41: 1136-1143. PMID: 6508504, DOI: 10.1001/archpsyc.1984.01790230022003.Peer-Reviewed Original ResearchConceptsAge of onsetMajor depressionNormal control subjectsRelatives of probandsFamilial loadingControl subjectsEarly-onset depressionFirst-degree relativesYears of ageHigh familial loadingHigh riskNormal subjectsSpecificity of transmissionEarly adulthoodDepressionProbandsAgeMore studiesFamily studiesYoung personOnsetLater ageHomogeneous disorderSubjectsInverse relationshipDepression and Anxiety Disorders in Parents and Children: Results From the Yale Family Study
Weissman M, Leckman J, Merikangas K, Gammon G, Prusoff B. Depression and Anxiety Disorders in Parents and Children: Results From the Yale Family Study. JAMA Psychiatry 1984, 41: 845-852. PMID: 6466043, DOI: 10.1001/archpsyc.1984.01790200027004.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersChildren of probandsPrimary major depressionAdult first-degree relativesRisk of depressionFirst-degree relativesNormal control groupYale Family StudyAdult panic disorderMajor depressionRecurrent depressionPsychiatric illnessControl groupFamilial loadingAdditional riskDisordersDepressionProbandsYoung childrenChildrenFamily studiesRiskParental assortative matingAgoraphobia