1987
Children of Depressed Parents: Increased Psychopathology and Early Onset of Major Depression
Weissman M, Gammon G, John K, Merikangas K, Warner V, Prusoff B, Sholomskas D. Children of Depressed Parents: Increased Psychopathology and Early Onset of Major Depression. JAMA Psychiatry 1987, 44: 847-853. PMID: 3662741, DOI: 10.1001/archpsyc.1987.01800220009002.Peer-Reviewed Original ResearchConceptsMajor depressionFemale subjectsProband's parentsYears of agePrepubertal depressionPrognostic significanceMean ageOverall prevalenceLower riskClinical strategiesPsychiatric diagnosisPsychiatric treatmentSymptom profilesDepressed probandsNormal probandsDepressed parentsPoor social functioningSubstance abuseEarly onsetDepressed childrenSubject diagnosisDiagnosisDepressionChild psychiatristsSocial functioning
1984
Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity
Weissman M, Wickramaratne P, Merikangas K, Leckman J, Prusoff B, Caruso K, Kidd K, Gammon G. Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity. JAMA Psychiatry 1984, 41: 1136-1143. PMID: 6508504, DOI: 10.1001/archpsyc.1984.01790230022003.Peer-Reviewed Original ResearchConceptsAge of onsetMajor depressionNormal control subjectsRelatives of probandsFamilial loadingControl subjectsEarly-onset depressionFirst-degree relativesYears of ageHigh familial loadingHigh riskNormal subjectsSpecificity of transmissionEarly adulthoodDepressionProbandsAgeMore studiesFamily studiesYoung personOnsetLater ageHomogeneous disorderSubjectsInverse relationship