Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity
Weissman M, Wickramaratne P, Merikangas K, Leckman J, Prusoff B, Caruso K, Kidd K, Gammon G. Onset of Major Depression in Early Adulthood: Increased Familial Loading and Specificity. JAMA Psychiatry 1984, 41: 1136-1143. PMID: 6508504, DOI: 10.1001/archpsyc.1984.01790230022003.Peer-Reviewed Original ResearchConceptsAge of onsetMajor depressionNormal control subjectsRelatives of probandsFamilial loadingControl subjectsEarly-onset depressionFirst-degree relativesYears of ageHigh familial loadingHigh riskNormal subjectsSpecificity of transmissionEarly adulthoodDepressionProbandsAgeMore studiesFamily studiesYoung personOnsetLater ageHomogeneous disorderSubjectsInverse relationshipDepression and Anxiety Disorders in Parents and Children: Results From the Yale Family Study
Weissman M, Leckman J, Merikangas K, Gammon G, Prusoff B. Depression and Anxiety Disorders in Parents and Children: Results From the Yale Family Study. JAMA Psychiatry 1984, 41: 845-852. PMID: 6466043, DOI: 10.1001/archpsyc.1984.01790200027004.Peer-Reviewed Original ResearchConceptsPanic disorderAnxiety disordersChildren of probandsPrimary major depressionAdult first-degree relativesRisk of depressionFirst-degree relativesNormal control groupYale Family StudyAdult panic disorderMajor depressionRecurrent depressionPsychiatric illnessControl groupFamilial loadingAdditional riskDisordersDepressionProbandsYoung childrenChildrenFamily studiesRiskParental assortative matingAgoraphobia