2016
Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins
Jensen KH, Brandt SS, Shigematsu H, Sigworth FJ. Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins. Journal Of Structural Biology 2016, 194: 49-60. PMID: 26835990, PMCID: PMC4866491, DOI: 10.1016/j.jsb.2016.01.012.Peer-Reviewed Original Research
2006
Using cryo-EM to measure the dipole potential of a lipid membrane
Wang L, Bose PS, Sigworth FJ. Using cryo-EM to measure the dipole potential of a lipid membrane. Proceedings Of The National Academy Of Sciences Of The United States Of America 2006, 103: 18528-18533. PMID: 17116859, PMCID: PMC1693696, DOI: 10.1073/pnas.0608714103.Peer-Reviewed Original ResearchMeSH KeywordsCryoelectron MicroscopyLipid BilayersLiposomesMembrane PotentialsOsmotic PressurePhosphatidylcholinesConceptsDipole potentialLipid membranesPhase-contrast imagingMolecular dynamics calculationsLipid bilayer membranesIon translocation ratesAtomic potentialLipid moleculesLipid monolayersBilayer membranesDynamics calculationsProbe methodSurface potentialAnionsDiphytanoylphosphatidylcholineCationsElectronsImage intensityAbsolute valueMembraneMoleculesConformationLarge permeabilityMonolayersBilayers
1991
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters
Heinemann S, Sigworth F. Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters. Biophysical Journal 1991, 60: 577-587. PMID: 1718467, PMCID: PMC1260101, DOI: 10.1016/s0006-3495(91)82087-2.Peer-Reviewed Original Research
1990
Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. Biophysical Journal 1990, 57: 499-514. PMID: 1689592, PMCID: PMC1280744, DOI: 10.1016/s0006-3495(90)82566-2.Peer-Reviewed Original Research
1989
Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins.
Shenkel S, Cooper E, James W, Agnew W, Sigworth F. Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 9592-9596. PMID: 2556720, PMCID: PMC298544, DOI: 10.1073/pnas.86.23.9592.Peer-Reviewed Original ResearchEstimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents
Heinemann S, Sigworth F. Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. Biochimica Et Biophysica Acta 1989, 987: 8-14. PMID: 2480817, DOI: 10.1016/0005-2736(89)90448-3.Peer-Reviewed Original Research