1996
Impaired slow inactivation in mutant sodium channels
Cummins T, Sigworth F. Impaired slow inactivation in mutant sodium channels. Biophysical Journal 1996, 71: 227-236. PMID: 8804606, PMCID: PMC1233474, DOI: 10.1016/s0006-3495(96)79219-6.Peer-Reviewed Original ResearchConceptsRat skeletal muscle channelsSodium currentProlonged depolarizationSlow inactivationPersistent sodium currentMaximal sodium currentSkeletal muscle channelsMuscle paralysisSkeletal muscle fibersMutant sodium channelsSustained currentHyperkalemic periodic paralysisM mutationPeriodic paralysisSodium channelsMuscle channelsMuscle fibersParalysisFast inactivationWild-type channelsMutant channelsDepolarization
1995
Charge movement in the sodium channel.
Sigworth F. Charge movement in the sodium channel. The Journal Of General Physiology 1995, 106: 1047-1051. PMID: 8786349, PMCID: PMC2229309, DOI: 10.1085/jgp.106.6.1047.Peer-Reviewed Original Research
1993
Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis
Cummins T, Zhou J, Sigworth F, Ukomadu C, Stephan M, Ptáčk L, Agnew W. Functional consequences of a Na+ channel mutation causing hyperkalemic periodic paralysis. Neuron 1993, 10: 667-678. PMID: 8386527, DOI: 10.1016/0896-6273(93)90168-q.Peer-Reviewed Original ResearchConceptsHyperkalemic periodic paralysisFifth transmembrane segmentHuman embryonic kidney 293 cellsSingle base pair substitutionsEmbryonic kidney 293 cellsKidney 293 cellsBase pair substitutionsTransmembrane segmentsHuman mutationsChannel cDNARat channelHuman skeletal muscleFunctional consequencesPair substitutionsSecond domainCorresponding regionChannel mutationsGenetic defectsMutationsSkeletal musclePeriodic paralysisPatch-clamp recordingsCDNARat musclePedigreeFluctuations in ion channel gating currents. Analysis of nonstationary shot noise
Crouzy S, Sigworth F. Fluctuations in ion channel gating currents. Analysis of nonstationary shot noise. Biophysical Journal 1993, 64: 68-76. PMID: 8381683, PMCID: PMC1262303, DOI: 10.1016/s0006-3495(93)81341-9.Peer-Reviewed Original Research
1991
Patch recordings from the electrocytes of Electrophorus electricus. Na currents and PNa/PK variability.
Shenkel S, Sigworth F. Patch recordings from the electrocytes of Electrophorus electricus. Na currents and PNa/PK variability. The Journal Of General Physiology 1991, 97: 1013-1041. PMID: 1650809, PMCID: PMC2216506, DOI: 10.1085/jgp.97.5.1013.Peer-Reviewed Original Research
1989
Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins.
Shenkel S, Cooper E, James W, Agnew W, Sigworth F. Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 9592-9596. PMID: 2556720, PMCID: PMC298544, DOI: 10.1073/pnas.86.23.9592.Peer-Reviewed Original ResearchPrimary structure and functional expression of a mammalian skeletal muscle sodium channel
Trimmer J, Cooperman S, Tomiko S, Zhou J, Crean S, Boyle M, Kalen R, Sheng Z, Barchi R, Sigworth F, Goodman R, Agnew W, Mandel G. Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron 1989, 3: 33-49. PMID: 2559760, DOI: 10.1016/0896-6273(89)90113-x.Peer-Reviewed Original ResearchConceptsAlpha subunitHomologous domains IAmino acid segmentSodium channelsSkeletal muscle sodium channelsNorthern blot analysisSkeletal muscleMuscle sodium channelsVoltage-sensitive sodium channelsPrimary structureFunctional expressionDomain IAcid segmentNative channelsSynthetic RNAXenopus oocytesRat muscle fibersBlot analysisRat skeletal muscleEel electroplaxRat brainSubunitsMuscle fibersMuscleCDNA