2009
Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy
Wang L, Sigworth FJ. Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature 2009, 461: 292-295. PMID: 19718020, PMCID: PMC2797367, DOI: 10.1038/nature08291.Peer-Reviewed Original ResearchConceptsVoltage sensor domainNative membrane environmentMembrane proteinsMembrane environmentChannel voltage-sensor domainElectron cryomicroscopyVoltage-activated potassium channelsSingle-particle electron cryomicroscopyIndividual protein particlesPotassium channelsBK potassium channelsLarge conductance calciumLipid membranesX-ray crystal structureBK channelsStructural studiesProtein particlesProteinCryomicroscopyCrystal structureFormation of crystalsDomainStructureCrystalsChannels
1988
Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels. Biophysical Journal 1988, 54: 757-764. PMID: 2465033, PMCID: PMC1330382, DOI: 10.1016/s0006-3495(88)83013-3.Peer-Reviewed Original ResearchConceptsBiological ion channelsGramicidin A channelsTime resolutionCurrent histogramFast time scaleOpen channel noiseCharacteristic timeNoise measurementsSingle-channel experimentsNoise experimentsDirect measurementTime scalesA channelsSpectral densityBandwidth limitationsCurrentTheoretical approachMeasurementsIon channelsBlocking processChannelsSingle-channel recordingsSingle-channel currentsNoiseDependence
1977
Sodium channels in nerve apparently have two conductance states
SIGWORTH F. Sodium channels in nerve apparently have two conductance states. Nature 1977, 270: 265-267. PMID: 593345, DOI: 10.1038/270265a0.Peer-Reviewed Original Research