2024
1895-LB: Fasting C-Peptide and Type 1 Diabetes Polygenic Score Predict Diabetic Ketoacidosis in People with Type 2 Diabetes in DECLARE-TIMI 58
MI KANG Y, MELLONI G, CAHN A, RAZ I, MOURA F, BHATT D, INZUCCHI S, LEITER L, MCGUIRE D, WILDING J, GAUSE-NILSSON I, OSCARSSON J, MARSTON N, RUFF C, SABATINE M, WIVIOTT S. 1895-LB: Fasting C-Peptide and Type 1 Diabetes Polygenic Score Predict Diabetic Ketoacidosis in People with Type 2 Diabetes in DECLARE-TIMI 58. Diabetes 2024, 73 DOI: 10.2337/db24-1895-lb.Peer-Reviewed Original ResearchRisk of DKADuke Clinical Research InstituteC-pepC-peptidePolygenic scoresClinical Research InstitutePopulation Health Research InstituteHigh-risk ptsFasting C-peptideHealth Research InstituteCV outcome trialsAmerican College of CardiologyHigher-risk groupsPredicting DKAType 2 diabetesCSL BehringDiabetic ketoacidosisFerring PharmaceuticalsBristol-Myers SquibbSt. Jude MedicalNon-HLAIncreased riskCleveland ClinicDapagliflozinAmerican College
2022
Abstract 12593: Type 2 Diabetes Mellitus Polygenic Score Predicts New Onset Diabetes in Patients With Established Atherosclerotic Cardiovascular Disease: A FOURIER Sub-Study
Moura F, Kamanu F, Wiviott S, Giugliano R, Florez J, Roselli C, Keech A, Lubitz S, Ellinor P, Ruff C, Marston N, Sabatine M. Abstract 12593: Type 2 Diabetes Mellitus Polygenic Score Predicts New Onset Diabetes in Patients With Established Atherosclerotic Cardiovascular Disease: A FOURIER Sub-Study. Circulation 2022, 146: a12593-a12593. DOI: 10.1161/circ.146.suppl_1.12593.Peer-Reviewed Original ResearchNew-onset T2DPolygenic scoresGenetic riskClinical risk factorsAtherosclerotic cardiovascular diseaseGenome-wide significant single nucleotide polymorphismsGenetic risk categoriesAmerican Diabetes Association definitionRisk factorsCardiovascular diseaseSignificant single nucleotide polymorphismsPredicting new-onset diabetesBMI levelsNew-onset diabetes casesAssociation definitionType 2 diabetesNormal weightBaseline ageDiabetes casesNew-onset diabetesPre-diabetesSub-studySingle nucleotide polymorphismsBMIT2D