2019
P4626Neuronal nitric oxide sintetase polymorphism increases sympathetic activity and recurrent cardiovascular events after myocardial infarction
Oliveira E, Munhoz D, Carvalho L, Moura F, Machado-Silva W, Figueiredo V, Nobrega O, Sposito A. P4626Neuronal nitric oxide sintetase polymorphism increases sympathetic activity and recurrent cardiovascular events after myocardial infarction. European Heart Journal 2019, 40: ehz745.1008. DOI: 10.1093/eurheartj/ehz745.1008.Peer-Reviewed Original ResearchST-elevation myocardial infarctionMajor cardiovascular eventsT allele carriersFlow-mediated dilationRecurrent major cardiovascular eventsCardiovascular eventsSympathetic activityClinical impactT alleleAcute phase of ST-elevation myocardial infarctionAssociated with increased sympathetic toneDecreased FMDMyocardial infarctionClinical follow-upCox regression analysisIncreased sympathetic activityNitric oxideRecurrent cardiovascular eventsAutonomic nervous system modulationCardiac sudden deathElevation myocardial infarctionDecreased parasympathetic activityPeripheral nervous systemSimvastatin doseSympathetic tone
2016
ST-elevation myocardial infarction risk in the very elderly
Campos A, Placido-Sposito A, Freitas W, Moura F, Guariento M, Nadruz W, Moriguchi E, Sposito A, Study O. ST-elevation myocardial infarction risk in the very elderly. BBA Clinical 2016, 6: 108-112. PMID: 27635386, PMCID: PMC5024138, DOI: 10.1016/j.bbacli.2016.09.001.Peer-Reviewed Original ResearchModerate to severe depressive symptomsST-segment elevation myocardial infarctionSevere depressive symptomsDepressive symptomsGlomerular filtration rateAttributable riskMortality of ST-segment elevation myocardial infarctionOdds ratioReduced levels of HDL-CHDL-CMild depressive symptomsMyocardial infarction riskMale genderLow HDL-CHigh LDL-CCase-control studyReduced HDL-CST-segment elevation myocardial infarction patientsMultivariate regression modelLow glomerular filtration rateAssociated with ST-segment elevation myocardial infarctionLevels of HDL-CInfarction riskElevation myocardial infarctionSmoking habits