2021
Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction
Nóbrega O, Campos-Staffico A, Oliveira E, Munhoz D, Moura F, Carvalho L, Soares A, Gomes C, Tonet-Furioso A, Sposito A, . Defective Allele of the Neuronal Nitric Oxide Synthase Gene Increases Insulin Resistance During Acute Phase of Myocardial Infarction. International Journal Of General Medicine 2021, 14: 3669-3676. PMID: 34321912, PMCID: PMC8312503, DOI: 10.2147/ijgm.s313661.Peer-Reviewed Original ResearchST-elevation myocardial infarctionFlow-mediated dilationNeuronal nitric oxide synthaseAcute phaseInsulin-resistant statesDefective allelesAssociated with poorer endothelial functionInsulin resistanceMyocardial infarctionAssociated with insulin-resistant statesInsulin sensitivityCirculating NO poolB cell functionAcute phase of myocardial infarctionNitric oxidePlasma NO levelsPredictors of mortalityPhase of myocardial infarctionPoorer endothelial functionBlood glucose balanceInfluence insulin responsivenessNitric oxide synthaseConsecutive patientsAA patientsGlycemic disorders
2013
Validation of surrogate indexes of insulin sensitivity in acute phase of myocardial infarction based on euglycemic-hyperinsulinemic clamp
Moura F, Carvalho L, Cintra R, Martins N, Figueiredo V, Quinaglia e Silva J, Almeida O, Coelho O, Sposito A. Validation of surrogate indexes of insulin sensitivity in acute phase of myocardial infarction based on euglycemic-hyperinsulinemic clamp. AJP Endocrinology And Metabolism 2013, 306: e399-e403. PMID: 24347056, DOI: 10.1152/ajpendo.00566.2013.Peer-Reviewed Original ResearchConceptsQuantitative insulin sensitivity check indexEuglycemic-hyperinsulinemic clampHomeostatic model assessmentHOMA-IRInsulin sensitivityMyocardial infarctionSurrogate indexHomeostatic model assessment of insulin resistanceModel assessment of insulin resistanceConsecutive nondiabetic patientsHomeostatic model assessment of insulin sensitivityAssessment of insulin resistanceST-segment elevation MISurrogate indexes of insulin sensitivityInsulin sensitivity check indexIndices of insulin sensitivityAcute phase of myocardial infarctionReceiver operating characteristic curveAcute MI patientsAssessment of insulin sensitivityPhase of myocardial infarctionGold standard reference methodBland-Altman plotsOperating characteristics curvePoor patient outcomesValidation of HOMA2S in acute phase of myocardial infarction, based on euglycemic-hyperinsulinemic clamp
Carvalho L, Moura F, Gomes N, Sposito A. Validation of HOMA2S in acute phase of myocardial infarction, based on euglycemic-hyperinsulinemic clamp. European Heart Journal 2013, 34: p1272. DOI: 10.1093/eurheartj/eht308.p1272.Peer-Reviewed Original ResearchAcute phase of MIEuglycemic-hyperinsulinemic clampPhase of MIMyocardial infarctionInsulin sensitivityAcute phaseST-segment elevation MIROC curveEvaluate blood glucose levelsArea under the curveAcute phase of myocardial infarctionHomeostasis model assessmentBland-Altman graphsPhase of myocardial infarctionBland-Altman analysisLinear regressionHyperinsulinemic-euglycemic clampHeart StudyGold standard methodBlood glucose levelsNondiabetic patientsStressful situationsCardiovascular eventsElevation MIEndothelial function
2011
Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction
Carvalho L, Cintra R, Araújo A, Moura F, Quináglia e Silva J, Coelho O, Sposito A. Abstract 18367: High Density Lipoprotein Independently Modulates Insulin Sensitivity and Secretion During Acute Phase of Myocardial Infarction. Circulation 2011, 124 DOI: 10.1161/circ.124.suppl_21.a18367.Peer-Reviewed Original ResearchHDL-C quartileHDL-CC-peptideMyocardial infarctionDisposition indexStress hyperglycemiaPlasma insulinInsulin sensitivityBlood glucoseConsecutive non-diabetic patientsAcute phaseHDL plasma levelsNon-diabetic patientsPlasma C-peptideAcute phase of MIAcute phase of myocardial infarctionHDL-C levelsST-elevation MIMultivariate analysis modelPhase of myocardial infarctionInfluence of HDLPhase of MIPlasma levelsTransient decreasePatientsHigh plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction
Carvalho L, Cintra R, Moura F, Martins N, Quinaglia e Silva J, Coelho O, Sposito A, Group O. High plasma HDL-C attenuates stress hyperglycemia during acute phase of myocardial infarction. Atherosclerosis 2011, 220: 231-236. PMID: 22018645, DOI: 10.1016/j.atherosclerosis.2011.09.044.Peer-Reviewed Original ResearchConceptsHDL-C levelsHDL-C quartilePlasma HDL-C levelsHDL-CC-peptideMyocardial infarctionAcute phaseStress hyperglycemiaInsulin sensitivityAssociated with HDL-C levelsConsecutive non-diabetic patientsNon-diabetic patientsAcute phase of MILow plasma HDL-C levelsAcute phase of myocardial infarctionST-segment elevationPhase of myocardial infarctionBeta-cell functionAssess insulin sensitivityPhase of MIImproved insulin sensitivityBlood glucose changesPlasma glucoseQuartilePlasma insulin