Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Avascular Necrosis in Sickle Cell Disease
Sowa A, Hu Y, Gladwin M, Gordeuk V, Nouraie S, Zhang Y, Pashankar F, Krishnamurti L, Gruen J. Genome-Wide Association Study Identifies Novel Genetic Variants Associated with Avascular Necrosis in Sickle Cell Disease. Blood 2024, 144: 5297-5297. DOI: 10.1182/blood-2024-207552.Peer-Reviewed Original ResearchGenome-wide association studiesChromosome 1Enhancer regionGenome-wide significance thresholdNon-coding RNA genesLong non-coding RNA genesGenome-wide significanceGenotype call rateHardy-Weinberg equilibriumSickle cell diseaseRNA genesLinkage disequilibriumPopulation stratificationAssociation studiesDiagnosis of sickle cell diseaseRegulatory elementsAvascular necrosisCohort of individualsGene studiesAllele frequenciesMultivariate logistic regression analysisLogistic regression analysisSNPsGenetic associationCall rate