2016
Neurovascular unit remodelling in the subacute stage of stroke recovery
Lake EMR, Bazzigaluppi P, Mester J, Thomason LAM, Janik R, Brown M, McLaurin J, Carlen PL, Corbett D, Stanisz GJ, Stefanovic B. Neurovascular unit remodelling in the subacute stage of stroke recovery. NeuroImage 2016, 146: 869-882. PMID: 27664828, DOI: 10.1016/j.neuroimage.2016.09.016.Peer-Reviewed Original ResearchConceptsPeri-lesional cortexVascular reactivityNeuronal lossSubacute stageEndothelin-1LFP activityLong-term functional outcomeLocal field potential responsesPeripheral somatosensory stimulationActivation of microgliaET-1 injectionFocal ischemic strokeFocal cerebral ischaemiaPeri-infarct zoneSensori-motor cortexSpontaneous neuronal activityAdult Sprague-DawleyField potential responsesExtended temporal windowDynamic functional changesIschemic strokeAstrocytic activationCerebral ischaemiaNeurovascular unitIschemic insult
2015
The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function
Lake E, Chaudhuri J, Thomason L, Janik R, Ganguly M, Brown M, McLaurin J, Corbett D, Stanisz GJ, Stefanovic B. The Effects of Delayed Reduction of Tonic Inhibition on Ischemic Lesion and Sensorimotor Function. Cerebrovascular And Brain Metabolism Reviews 2015, 35: 1601-1609. PMID: 25966952, PMCID: PMC4640317, DOI: 10.1038/jcbfm.2015.86.Peer-Reviewed Original ResearchConceptsIschemic lesionsFocal ischemiaEndothelin-1Rat modelMontoya staircase testWeeks of treatmentTotal stroke volumeCortical microinjectionsIschemic strokeChronic stageSensorimotor deficitsStroke recoveryTonic inhibitionSensorimotor functionStroke volumeGABAA antagonismGABA antagonismStaircase testPerilesional regionsDelayed reductionInverse agonistNecrotic coreBrain structuresBeneficial effectsStroke