2020
Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition
Akoumianakis I, Badi I, Douglas G, Chuaiphichai S, Herdman L, Akawi N, Margaritis M, Antonopoulos AS, Oikonomou EK, Psarros C, Galiatsatos N, Tousoulis D, Kardos A, Sayeed R, Krasopoulos G, Petrou M, Schwahn U, Wohlfart P, Tennagels N, Channon KM, Antoniades C. Insulin-induced vascular redox dysregulation in human atherosclerosis is ameliorated by dipeptidyl peptidase 4 inhibition. Science Translational Medicine 2020, 12 PMID: 32350133, PMCID: PMC7212010, DOI: 10.1126/scitranslmed.aav8824.Peer-Reviewed Original ResearchConceptsDipeptidyl peptidase-4 inhibitorsCoronary artery bypass surgeryAggressive insulin treatmentInsulin treatmentCoronary atherosclerosisEndothelial functionAbnormal responseHigh-fat diet-fed ApoEOral dipeptidyl peptidase-4 inhibitorLong-term combination therapyHuman internal mammary arteryDipeptidyl peptidase-4 inhibitionHigher cardiac mortalityPeptidase-4 inhibitionVascular insulin responsesVascular redox stateArtery bypass surgeryInternal mammary arteryInsulin resistance statusNitric oxide bioavailabilityPeptidase-4 inhibitorsPlasma DPP4 activityVascular oxidative stressRecent clinical trialsInsulin-sensitizing effects
2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signalingCardiac Computed Tomography
Oikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.Peer-Reviewed Original ResearchConceptsCardiac computed tomographyComputed tomographyCoronary atherosclerosisCoronary plaque burdenAcute coronary syndromeCoronary artery diseaseFirst-line diagnostic testUnstable coronary plaquesMorphological plaque featuresCoronary syndromeInflammatory burdenArterial inflammationArtery diseaseCoronary lesionsPlaque burdenPlaque featuresPrognostic implicationsCoronary plaquesPerivascular fatHemodynamic significanceVulnerable plaquesDiagnostic testsMajor causeTomographyCurrent role
2017
Stem Cell Therapy for Congenital Heart Disease
Tsilimigras DI, Oikonomou EK, Moris D, Schizas D, Economopoulos KP, Mylonas KS. Stem Cell Therapy for Congenital Heart Disease. Circulation 2017, 136: 2373-2385. PMID: 29229621, DOI: 10.1161/circulationaha.117.029607.BooksConceptsCongenital heart diseaseCell therapyHeart diseaseClinical trialsGold standard treatment modalityHypoplastic left heart syndromePulmonary artery hypertensionRight ventricle dysfunctionStandard treatment modalityAlternative treatment optionLarge clinical studiesStem cell deliveryQuality of lifeCell-based therapeutic strategiesArtery hypertensionStem cell-based therapeutic strategiesVentricle dysfunctionSurgical palliationVolume overloadHeart syndromeSafety profileCell-seeded graftsCochrane LibraryTreatment optionsTreatment modalities