2022
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Kotanidis CP, Xie C, Alexander D, Rodrigues JCL, Burnham K, Mentzer A, O’Connor D, Knight J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou EK, Badi I, Lyasheva M, Shirodaria C, Lumley SF, Constantinides B, Sanderson N, Rodger G, Chau KK, Lodge A, Tsakok M, Gleeson F, Adlam D, Rao P, Indrajeet D, Deshpande A, Bajaj A, Hudson BJ, Srivastava V, Farid S, Krasopoulos G, Sayeed R, Ho LP, Neubauer S, Newby DE, Channon KM, Deanfield J, Antoniades C, Consortium C, Ahern D, Ai Z, Ainsworth M, Allan C, Allcock A, Angus B, Ansari M, Arancibia-Cárcamo C, Aschenbrenner D, Attar M, Baillie J, Barnes E, Bashford-Rogers R, Bashyal A, Beer S, Berridge G, Beveridge A, Bibi S, Bicanic T, Blackwell L, Bowness P, Brent A, Brown A, Broxholme J, Buck D, Burnham K, Byrne H, Camara S, Ferreira I, Charles P, Chen W, Chen Y, Chong A, Clutterbuck E, Coles M, Conlon C, Cornall R, Cribbs A, Curion F, Davenport E, Davidson N, Davis S, Dendrou C, Dequaire J, Dib L, Docker J, Dold C, Dong T, Downes D, Drakesmith H, Dunachie S, Duncan D, Eijsbouts C, Esnouf R, Espinosa A, Etherington R, Fairfax B, Fairhead R, Fang H, Fassih S, Felle S, Mendoza M, Ferreira R, Fischer R, Foord T, Forrow A, Frater J, Fries A, Sanchez V, Garner L, Geeves C, Georgiou D, Godfrey L, Golubchik T, Vazquez M, Green A, Harper H, Harrington H, Heilig R, Hester S, Hill J, Hinds C, Hird C, Ho L, Hoekzema R, Hollis B, Hughes J, Hutton P, Jackson-Wood M, Jainarayanan A, James-Bott A, Jansen K, Jeffery K, Jones E, Jostins L, Kerr G, Kim D, Klenerman P, Knight J, Kumar V, Sharma P, Kurupati P, Kwok A, Lee A, Linder A, Lockett T, Lonie L, Lopopolo M, Lukoseviciute M, Luo J, Marinou S, Marsden B, Martinez J, Matthews P, Mazurczyk M, McGowan S, McKechnie S, Mead A, Mentzer A, Mi Y, Monaco C, Montadon R, Napolitani G, Nassiri I, Novak A, O'Brien D, O'Connor D, O'Donnell D, Ogg G, Overend L, Park I, Pavord I, Peng Y, Penkava F, Pinho M, Perez E, Pollard A, Powrie F, Psaila B, Quan T, Repapi E, Revale S, Silva-Reyes L, Richard J, Rich-Griffin C, Ritter T, Rollier C, Rowland M, Ruehle F, Salio M, Sansom S, Peres R, Delgado A, Sauka-Spengler T, Schwessinger R, Scozzafava G, Screaton G, Seigal A, Semple M, Sergeant M, Karali C, Sims D, Skelly D, Slawinski H, Sobrinodiaz A, Sousos N, Stafford L, Stockdale L, Strickland M, Sumray O, Sun B, Taylor C, Taylor S, Taylor A, Thongjuea S, Thraves H, Todd J, Tomic A, Tong O, Trebes A, Trzupek D, Tucci F, Turtle L, Udalova I, Uhlig H, van Grinsven E, Vendrell I, Verheul M, Voda A, Wang G, Wang L, Wang D, Watkinson P, Watson R, Weinberger M, Whalley J, Witty L, Wray K, Xue L, Yeung H, Yin Z, Young R, Youngs J, Zhang P, Zurke Y, investigators O, Banning A, Antonopoulos A, Bajaj A, Kelion A, Deshpande A, Kardos A, Hudson B, Koo B, Shirodaria C, Xie C, Kotanidis C, Mahon C, Berry C, Adlam D, Newby D, Connolly D, Scaletta D, Alexander D, Nicol E, McAlindon E, Oikonomou E, Pugliese F, Pontone G, Benedetti G, He G, West H, Kondo H, Benedek I, Das I, Deanfield J, Graby J, Greenwood J, Rodrigues J, Ge J, Channon K, Fabritz L, Fan L, Kingham L, Guglielmo M, Lyasheva M, Schmitt M, Beer M, Anderson M, Desai M, Marwan M, Takahashi N, Mehta N, Dai N, Screaton N, Sabharwal N, Maurovich-Horvat P, Rao P, Kotronias R, Kharbanda R, Preston R, Wood R, Blankstein R, Rajani R, Mirsadraee S, Munir S, Thomas S, Neubauer S, Klömpken S, Petersen S, Achenbach S, Anthony S, Mak S, Mittal T, Benedek T, Sharma V, Lin W. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. The Lancet Digital Health 2022, 4: e705-e716. PMID: 36038496, PMCID: PMC9417284, DOI: 10.1016/s2589-7500(22)00132-7.Peer-Reviewed Original ResearchConceptsInternal mammary arteryVascular inflammationSARS-CoV-2 variantsPrognostic valueHospital mortalityMammary arteryCT angiogramDexamethasone treatmentCOVID-19Angiography scansHuman internal mammary arteryB.1.1.7 SARS-CoV-2 variantNon-invasive imaging biomarkersBlood transcriptional modulesCytokine-driven inflammationDysregulation of coagulationAdverse clinical outcomesLong-term complicationsBritish Heart FoundationPulmonary CT angiographyNational Health Service TrustPlatelet aggregation pathwaysHealth Service TrustCT angiography scansUK National Health Service Trusts
2021
Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication A Meta-Analysis
Antonopoulos A, Angelopoulos A, Papanikolaou P, Simantiris S, Oikonomou E, Vamvakaris K, Koumpoura A, Farmaki M, Trivella M, Vlachopoulos C, Tsioufis K, Antoniades C, Tousoulis D. Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication A Meta-Analysis. JACC Cardiovascular Imaging 2021, 15: 460-471. PMID: 34801448, DOI: 10.1016/j.jcmg.2021.09.014.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseVascular inflammationInflammatory biomarkersRisk stratificationPrognostic valueClinical risk factorsNet clinical benefitValue of biomarkersUse of biomarkersMeasurement of biomarkersMeta-regression analysisLack of reportingCardiovascular eventsCohort studyStable patientsEvent incidenceRisk prognosticationClinical benefitHeart diseaseRisk factorsRisk discriminationClinical practiceInflammationSuch biomarkersMeta-AnalysisStandardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device
Oikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, Siddique M, Klüner LV, Shirodaria C, Mavrogiannis MC, Thomas S, Fava A, Deanfield J, Channon KM, Neubauer S, Desai MY, Achenbach S, Antoniades C. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular Research 2021, 117: 2677-2690. PMID: 34450625, DOI: 10.1093/cvr/cvab286.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdiposityAdolescentAdultAgedAged, 80 and overAlgorithmsCloud ComputingComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDecision Support TechniquesEnglandFemaleGermanyHeart Disease Risk FactorsHumansInflammationMaleMiddle AgedNomogramsOhioPredictive Value of TestsPrognosisRisk AssessmentTime FactorsYoung AdultConceptsFat attenuation indexPerivascular fat attenuation indexRisk factor-based modelCoronary artery inflammationClinical risk factorsFatal cardiac eventsCoronary artery diseaseCoronary inflammationRisk factorsFAI scorePlaque metricsCardiac eventsArtery inflammationAbsolute riskCoronary arteryClinical careNon-invasive detectionTraditional cardiovascular risk factorsPatient's absolute riskCardiovascular risk factorsFat compositionNet clinical benefitCardiovascular risk predictionDecision curve analysisFirst-line modality
2019
Cardiac Computed Tomography
Oikonomou EK, West HW, Antoniades C. Cardiac Computed Tomography. Arteriosclerosis Thrombosis And Vascular Biology 2019, 39: 2207-2219. PMID: 31510795, DOI: 10.1161/atvbaha.119.312899.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac computed tomographyComputed tomographyCoronary atherosclerosisCoronary plaque burdenAcute coronary syndromeCoronary artery diseaseFirst-line diagnostic testUnstable coronary plaquesMorphological plaque featuresCoronary syndromeInflammatory burdenArterial inflammationArtery diseaseCoronary lesionsPlaque burdenPlaque featuresPrognostic implicationsCoronary plaquesPerivascular fatHemodynamic significanceVulnerable plaquesDiagnostic testsMajor causeTomographyCurrent roleAssociation of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index
Elnabawi YA, Oikonomou EK, Dey AK, Mancio J, Rodante JA, Aksentijevich M, Choi H, Keel A, Erb-Alvarez J, Teague HL, Joshi AA, Playford MP, Lockshin B, Choi AD, Gelfand JM, Chen MY, Bluemke DA, Shirodaria C, Antoniades C, Mehta NN. Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index. JAMA Cardiology 2019, 4: 885-891. PMID: 31365032, PMCID: PMC6669789, DOI: 10.1001/jamacardio.2019.2589.Peer-Reviewed Original ResearchConceptsPerivascular fat attenuation indexFat attenuation indexBiologic psoriasis therapyBiologic therapyCoronary inflammationSevere psoriasisPsoriasis therapyCoronary plaquesSkin diseasesAnti-tumor necrosis factor αChronic inflammatory skin diseaseDifferent biologic agentsTraditional risk scoresCoronary plaque burdenLow cardiovascular riskProspective cohort studyAnti-inflammatory effectsCoronary artery diseaseInflammatory skin diseaseCoronary atherosclerotic plaquesNecrosis factor αSevere skin diseaseCardiovascular eventsCardiovascular riskCohort study
2017
Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia
Toutouzas K, Skoumas J, Koutagiar I, Benetos G, Pianou N, Georgakopoulos A, Galanakos S, Antonopoulos A, Drakopoulou M, Oikonomou EK, Kafouris P, Athanasiadis E, Metaxas M, Spyrou G, Pallantza Z, Galiatsatos N, Aggeli C, Antoniades C, Keramida G, Peters AM, Anagnostopoulos CD, Tousoulis D. Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia. Journal Of Clinical Lipidology 2017, 12: 33-43. PMID: 29174439, DOI: 10.1016/j.jacl.2017.10.019.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBone MarrowC-Reactive ProteinCase-Control StudiesFemaleHeterozygoteHumansHydroxymethylglutaryl-CoA Reductase InhibitorsHyperlipidemia, Familial CombinedHyperlipoproteinemia Type IIInflammationLipoproteins, LDLLiverMaleMiddle AgedPositron Emission Tomography Computed TomographySpleenConceptsHeFH patientsFDG uptakeAortic TBRVascular inflammationBone marrowFamilial dyslipidemiaHigher low-density lipoprotein levelsF-fluorodeoxyglucose positron emission tomography/High-sensitivity C-reactive proteinBone marrow FDG uptakeLow-density lipoprotein levelsPositron emission tomography/C-reactive proteinHigh FDG uptakeHeterozygous familial hypercholesterolemiaLow-density lipoproteinHepatic metabolic activityHematopoietic organsHigh liver uptakeDyslipidemic groupAdult patientsCardiovascular riskInflammatory biomarkersSerum lipidsAccelerated atherogenesisDetecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammation
2016
Inflammatory cytokines in atherosclerosis: current therapeutic approaches
Tousoulis D, Oikonomou E, Economou EK, Crea F, Kaski JC. Inflammatory cytokines in atherosclerosis: current therapeutic approaches. European Heart Journal 2016, 37: 1723-1732. PMID: 26843277, DOI: 10.1093/eurheartj/ehv759.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic inflammatory diseaseCurrent therapeutic approachesPathogenesis of atherosclerosisRole of cytokinesCardiovascular disease progressionTreatment of atherosclerosisPotential clinical significanceSmooth muscle cellsInflammatory cascadeInflammatory cytokinesInflammatory diseasesDisease progressionClinical significanceTherapeutic approachesAtherosclerotic plaquesColchicine actAtherosclerosisMuscle cellsCytokinesTypes of cellsSpecific antibodiesKey moleculesMultiple effectsCellsStatins