Featured Publications
Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity
Oikonomou EK, Kokkinidis DG, Kampaktsis PN, Amir EA, Marwick TH, Gupta D, Thavendiranathan P. Assessment of Prognostic Value of Left Ventricular Global Longitudinal Strain for Early Prediction of Chemotherapy-Induced Cardiotoxicity. JAMA Cardiology 2019, 4: 1007-1018. PMID: 31433450, PMCID: PMC6705141, DOI: 10.1001/jamacardio.2019.2952.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionGlobal longitudinal strainLeft ventricular global longitudinal strainVentricular global longitudinal strainPrognostic valueCutoff valuePublication biasMeasurement of GLSNew-onset heart failure symptomsAbsolute global longitudinal strainWorse global longitudinal strainLarge prospective multicenter studyLeft ventricular ejection fractionDiscriminatory performanceLongitudinal strainChemotherapy-Induced CardiotoxicityGLS cutoff valueSubclinical ventricular dysfunctionHeart failure symptomsProspective multicenter studyVentricular ejection fractionCochrane Library databasesRisk of biasOptimal cutoff valueBetter prognostic performance
2022
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19
Kotanidis CP, Xie C, Alexander D, Rodrigues JCL, Burnham K, Mentzer A, O’Connor D, Knight J, Siddique M, Lockstone H, Thomas S, Kotronias R, Oikonomou EK, Badi I, Lyasheva M, Shirodaria C, Lumley SF, Constantinides B, Sanderson N, Rodger G, Chau KK, Lodge A, Tsakok M, Gleeson F, Adlam D, Rao P, Indrajeet D, Deshpande A, Bajaj A, Hudson BJ, Srivastava V, Farid S, Krasopoulos G, Sayeed R, Ho LP, Neubauer S, Newby DE, Channon KM, Deanfield J, Antoniades C, Consortium C, Ahern D, Ai Z, Ainsworth M, Allan C, Allcock A, Angus B, Ansari M, Arancibia-Cárcamo C, Aschenbrenner D, Attar M, Baillie J, Barnes E, Bashford-Rogers R, Bashyal A, Beer S, Berridge G, Beveridge A, Bibi S, Bicanic T, Blackwell L, Bowness P, Brent A, Brown A, Broxholme J, Buck D, Burnham K, Byrne H, Camara S, Ferreira I, Charles P, Chen W, Chen Y, Chong A, Clutterbuck E, Coles M, Conlon C, Cornall R, Cribbs A, Curion F, Davenport E, Davidson N, Davis S, Dendrou C, Dequaire J, Dib L, Docker J, Dold C, Dong T, Downes D, Drakesmith H, Dunachie S, Duncan D, Eijsbouts C, Esnouf R, Espinosa A, Etherington R, Fairfax B, Fairhead R, Fang H, Fassih S, Felle S, Mendoza M, Ferreira R, Fischer R, Foord T, Forrow A, Frater J, Fries A, Sanchez V, Garner L, Geeves C, Georgiou D, Godfrey L, Golubchik T, Vazquez M, Green A, Harper H, Harrington H, Heilig R, Hester S, Hill J, Hinds C, Hird C, Ho L, Hoekzema R, Hollis B, Hughes J, Hutton P, Jackson-Wood M, Jainarayanan A, James-Bott A, Jansen K, Jeffery K, Jones E, Jostins L, Kerr G, Kim D, Klenerman P, Knight J, Kumar V, Sharma P, Kurupati P, Kwok A, Lee A, Linder A, Lockett T, Lonie L, Lopopolo M, Lukoseviciute M, Luo J, Marinou S, Marsden B, Martinez J, Matthews P, Mazurczyk M, McGowan S, McKechnie S, Mead A, Mentzer A, Mi Y, Monaco C, Montadon R, Napolitani G, Nassiri I, Novak A, O'Brien D, O'Connor D, O'Donnell D, Ogg G, Overend L, Park I, Pavord I, Peng Y, Penkava F, Pinho M, Perez E, Pollard A, Powrie F, Psaila B, Quan T, Repapi E, Revale S, Silva-Reyes L, Richard J, Rich-Griffin C, Ritter T, Rollier C, Rowland M, Ruehle F, Salio M, Sansom S, Peres R, Delgado A, Sauka-Spengler T, Schwessinger R, Scozzafava G, Screaton G, Seigal A, Semple M, Sergeant M, Karali C, Sims D, Skelly D, Slawinski H, Sobrinodiaz A, Sousos N, Stafford L, Stockdale L, Strickland M, Sumray O, Sun B, Taylor C, Taylor S, Taylor A, Thongjuea S, Thraves H, Todd J, Tomic A, Tong O, Trebes A, Trzupek D, Tucci F, Turtle L, Udalova I, Uhlig H, van Grinsven E, Vendrell I, Verheul M, Voda A, Wang G, Wang L, Wang D, Watkinson P, Watson R, Weinberger M, Whalley J, Witty L, Wray K, Xue L, Yeung H, Yin Z, Young R, Youngs J, Zhang P, Zurke Y, investigators O, Banning A, Antonopoulos A, Bajaj A, Kelion A, Deshpande A, Kardos A, Hudson B, Koo B, Shirodaria C, Xie C, Kotanidis C, Mahon C, Berry C, Adlam D, Newby D, Connolly D, Scaletta D, Alexander D, Nicol E, McAlindon E, Oikonomou E, Pugliese F, Pontone G, Benedetti G, He G, West H, Kondo H, Benedek I, Das I, Deanfield J, Graby J, Greenwood J, Rodrigues J, Ge J, Channon K, Fabritz L, Fan L, Kingham L, Guglielmo M, Lyasheva M, Schmitt M, Beer M, Anderson M, Desai M, Marwan M, Takahashi N, Mehta N, Dai N, Screaton N, Sabharwal N, Maurovich-Horvat P, Rao P, Kotronias R, Kharbanda R, Preston R, Wood R, Blankstein R, Rajani R, Mirsadraee S, Munir S, Thomas S, Neubauer S, Klömpken S, Petersen S, Achenbach S, Anthony S, Mak S, Mittal T, Benedek T, Sharma V, Lin W. Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19. The Lancet Digital Health 2022, 4: e705-e716. PMID: 36038496, PMCID: PMC9417284, DOI: 10.1016/s2589-7500(22)00132-7.Peer-Reviewed Original ResearchConceptsInternal mammary arteryVascular inflammationSARS-CoV-2 variantsPrognostic valueHospital mortalityMammary arteryCT angiogramDexamethasone treatmentCOVID-19Angiography scansHuman internal mammary arteryB.1.1.7 SARS-CoV-2 variantNon-invasive imaging biomarkersBlood transcriptional modulesCytokine-driven inflammationDysregulation of coagulationAdverse clinical outcomesLong-term complicationsBritish Heart FoundationPulmonary CT angiographyNational Health Service TrustPlatelet aggregation pathwaysHealth Service TrustCT angiography scansUK National Health Service Trusts
2021
Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication A Meta-Analysis
Antonopoulos A, Angelopoulos A, Papanikolaou P, Simantiris S, Oikonomou E, Vamvakaris K, Koumpoura A, Farmaki M, Trivella M, Vlachopoulos C, Tsioufis K, Antoniades C, Tousoulis D. Biomarkers of Vascular Inflammation for Cardiovascular Risk Prognostication A Meta-Analysis. JACC Cardiovascular Imaging 2021, 15: 460-471. PMID: 34801448, DOI: 10.1016/j.jcmg.2021.09.014.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseVascular inflammationInflammatory biomarkersRisk stratificationPrognostic valueClinical risk factorsNet clinical benefitValue of biomarkersUse of biomarkersMeasurement of biomarkersMeta-regression analysisLack of reportingCardiovascular eventsCohort studyStable patientsEvent incidenceRisk prognosticationClinical benefitHeart diseaseRisk factorsRisk discriminationClinical practiceInflammationSuch biomarkersMeta-AnalysisImpaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.
Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.Peer-Reviewed Original ResearchConceptsReduced Myocardial Flow ReserveMyocardial flow reserveRaynaud's phenomenonPrimary Raynaud's phenomenonSecondary Raynaud's phenomenonPatient controlsHealthy participantsFlow reservePositron Emission Tomography/Computed TomographyEmission Tomography/Computed TomographyTomography/Computed TomographyPositron emission tomography/Impaired Myocardial Flow ReserveCoronary microvascular dysfunctionLarge prospective studiesMultivariable logistic regressionEmission tomography/PET/CTSSc-RPMicrovascular dysfunctionClinical predictorsIndependent predictorsSystemic sclerosisPrognostic valueProspective studyAssessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography
Klüner LV, Oikonomou EK, Antoniades C. Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography. Radiology Cardiothoracic Imaging 2021, 3: e200563. PMID: 33778665, PMCID: PMC7977699, DOI: 10.1148/ryct.2021200563.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCoronary inflammationPrognostic valueHigh-risk plaque featuresCoronary Artery Disease ReportingAnti-inflammatory interventionsTraditional risk factorsFirst-line diagnostic testSignificant prognostic valueChest painDisease activityCoronary atherosclerosisSecondary preventionPlaque featuresCCTA analysisCoronary arteryCoronary calciumRisk factorsObservational studyRisk discriminationCT angiographyAdipose tissueInflammation
2019
The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis
Papanastasiou CA, Kokkinidis DG, Kampaktsis PN, Bikakis I, Cunha DK, Oikonomou EK, Greenwood JP, Garcia MJ, Karamitsos TD. The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis. JACC Cardiovascular Imaging 2019, 13: 385-392. PMID: 31326491, DOI: 10.1016/j.jcmg.2019.03.029.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementAortic stenosisCardiac magnetic resonanceCause mortalityGadolinium enhancementLGE-CMRSystematic reviewA Systematic ReviewStrongest univariate predictorsRandom-effects modelBaseline characteristicsHazard ratioPrognostic roleRisk stratificationAdverse outcomesPrognostic valueUnivariate predictorsPooled analysisMyocardial fibrosisInclusion criteriaCardiac diseaseRegional fibrosisPatientsElectronic databasesMeta-Analysis
2017
Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review
Papanastasiou CA, Kokkinidis DG, Oikonomou EK, Mantziaris VG, Foley TR, Karamitsos TD, Waldo SW, Armstrong EJ. Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review. Biomarkers 2017, 23: 1-9. PMID: 29144175, DOI: 10.1080/1354750x.2017.1397194.Peer-Reviewed Original ResearchConceptsIschemic chest painChest painCardiovascular eventsAdverse eventsShort-term adverse eventsShort-term risk stratificationAdverse cardiovascular eventsAcute coronary syndromeGroup of patientsIdentification of patientsStandardized clinical studiesElectronic databases MEDLINEFuture adverse eventsPlasma proteinsCause mortalityCoronary syndromeIschemic originRisk stratificationPrognostic valueCochrane LibraryPatient populationClinical studiesInclusion criteriaPrognostic biomarkerPain