2024
A Multicenter Evaluation of the Impact of Therapies on Deep Learning-based Electrocardiographic Hypertrophic Cardiomyopathy Markers
Dhingra L, Sangha V, Aminorroaya A, Bryde R, Gaballa A, Ali A, Mehra N, Krumholz H, Sen S, Kramer C, Martinez M, Desai M, Oikonomou E, Khera R. A Multicenter Evaluation of the Impact of Therapies on Deep Learning-based Electrocardiographic Hypertrophic Cardiomyopathy Markers. The American Journal Of Cardiology 2024 PMID: 39581517, DOI: 10.1016/j.amjcard.2024.11.028.Peer-Reviewed Original ResearchCleveland Clinic FoundationHypertrophic cardiomyopathyMedian follow-up periodHypertrophic cardiomyopathy therapyMonitoring treatment responseFollow-up periodImpact of therapyAtlantic Health SystemLack of improvementOral alternativePost-SRTMedical therapyTreatment responseMulticenter evaluationInterventricular septumPercutaneous reductionMavacamtenTherapyPatientsClinic FoundationPoint-of-care monitoringECGECG imagesScoresHealth system
2022
Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes.
Oikonomou EK, Suchard MA, McGuire DK, Khera R. Phenomapping-Derived Tool to Individualize the Effect of Canagliflozin on Cardiovascular Risk in Type 2 Diabetes. Diabetes Care 2022, 45: 965-974. PMID: 35120199, PMCID: PMC9016734, DOI: 10.2337/dc21-1765.Peer-Reviewed Original ResearchConceptsCanagliflozin Cardiovascular Assessment StudyMajor adverse cardiovascular eventsType 2 diabetesHazard ratioSodium-glucose cotransporter 2 inhibitorsCardiovascular disease benefitAdverse cardiovascular eventsCotransporter 2 inhibitorsEffects of canagliflozinCanagliflozin dosesCanagliflozin's effectsCardiovascular eventsCardiovascular riskPatients 5Cardioprotective effectsSGLT2 inhibitorsDisease benefitBaseline variablesOriginal trialCanagliflozinType 2DiabetesPatientsRisk estimatesEffect estimates
2020
Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease
Oikonomou EK, Siddique M, Antoniades C. Artificial intelligence in medical imaging: A radiomic guide to precision phenotyping of cardiovascular disease. Cardiovascular Research 2020, 116: 2040-2054. PMID: 32090243, PMCID: PMC7585409, DOI: 10.1093/cvr/cvaa021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiac computed tomographyNon-invasive imagingCardiovascular imagingCardiovascular diseaseNon-invasive cardiovascular imagingCardiac CTCardiovascular risk stratificationFirst-line optionImportant clinical implicationsRisk stratificationUnstable patientsClinical careComputed tomographyCurrent evidenceClinical implicationsCardiac imagingRadiomics approachPatientsRadiomics methodTissue biologyCardiovascular diagnosticsDiseaseFuture studiesImagingPhenotyping
2019
The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis
Papanastasiou CA, Kokkinidis DG, Kampaktsis PN, Bikakis I, Cunha DK, Oikonomou EK, Greenwood JP, Garcia MJ, Karamitsos TD. The Prognostic Role of Late Gadolinium Enhancement in Aortic Stenosis A Systematic Review and Meta-Analysis. JACC Cardiovascular Imaging 2019, 13: 385-392. PMID: 31326491, DOI: 10.1016/j.jcmg.2019.03.029.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementAortic stenosisCardiac magnetic resonanceCause mortalityGadolinium enhancementLGE-CMRSystematic reviewA Systematic ReviewStrongest univariate predictorsRandom-effects modelBaseline characteristicsHazard ratioPrognostic roleRisk stratificationAdverse outcomesPrognostic valueUnivariate predictorsPooled analysisMyocardial fibrosisInclusion criteriaCardiac diseaseRegional fibrosisPatientsElectronic databasesMeta-AnalysisMyocarditis Surveillance in Patients with Advanced Melanoma on Combination Immune Checkpoint Inhibitor Therapy: The Memorial Sloan Kettering Cancer Center Experience
Chuy K, Oikonomou EK, Postow MA, Callahan MK, Chapman PB, Shoushtari AN, Neilan TG, Fradley MG, Ramanathan LV, Wolchok JD, Steingart RM, Gupta D. Myocarditis Surveillance in Patients with Advanced Melanoma on Combination Immune Checkpoint Inhibitor Therapy: The Memorial Sloan Kettering Cancer Center Experience. The Oncologist 2019, 24: e196-e197. PMID: 30910868, PMCID: PMC6516118, DOI: 10.1634/theoncologist.2019-0040.Peer-Reviewed Original ResearchConceptsCombination immune checkpoint inhibitor therapyImmune checkpoint inhibitor therapyCheckpoint inhibitor therapyInhibitor therapyMemorial Sloan-Kettering Cancer Center experienceCancer Center experienceSafety Working GroupAdvanced melanomaCenter experienceConsensus documentPatientsTherapyWorking GroupMyocarditisMelanoma
2017
Role of deferred stenting in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta‐analysis
De Maria GL, Alkhalil M, Oikonomou EK, Wolfrum M, Choudhury RP, Banning AP. Role of deferred stenting in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta‐analysis. Journal Of Interventional Cardiology 2017, 30: 264-273. PMID: 28370496, DOI: 10.1111/joic.12380.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionHard clinical endpointsImmediate stentingAngiographic endpointsClinical endpointsST-elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionRandomized clinical trialsCoronary interventionMyocardial infarctionClinical trialsImproved outcomesElectronic databasesFlow restorationPatientsEndpointStentingSTEMIInfarctionRecent publicationsTrials
2016
Prognostic implications of epicardial fat volume quantification in acute pericarditis
Lazaros G, Antonopoulos AS, Oikonomou EK, Vasileiou P, Oikonomou E, Stroumpouli E, Karavidas A, Antoniades C, Tousoulis D. Prognostic implications of epicardial fat volume quantification in acute pericarditis. European Journal Of Clinical Investigation 2016, 47: 129-136. PMID: 27931089, DOI: 10.1111/eci.12711.Peer-Reviewed Original ResearchConceptsEpicardial fat volumeCardiac computerized tomographyComposite clinical endpointAcute pericarditisIncessant pericarditisChest painPrognostic implicationsClinical endpointsPoor responsePericardial effusion sizeOutcomes of patientsAtrial fibrillation developmentImportant prognostic implicationsCardiovascular disease pathogenesisAnti-inflammatory drugsLower odds ratioFifty patientsClinical featuresEffusion sizeFirst diagnosisPrognostic informationOdds ratioPericarditisFat volumePatients