2024
Development and multinational validation of an algorithmic strategy for high Lp(a) screening
Aminorroaya A, Dhingra L, Oikonomou E, Saadatagah S, Thangaraj P, Vasisht Shankar S, Spatz E, Khera R. Development and multinational validation of an algorithmic strategy for high Lp(a) screening. Nature Cardiovascular Research 2024, 3: 558-566. PMID: 39195936, DOI: 10.1038/s44161-024-00469-1.Peer-Reviewed Original ResearchElectronic health recordsAssociated with premature atherosclerotic cardiovascular diseaseElevated Lp(aHealth recordsUK BiobankPremature atherosclerotic cardiovascular diseaseMachine learning modelsAtherosclerotic cardiovascular diseaseCohort studyReal-world settingsTargeted screeningCardiovascular diseaseLearning modelsNovel targeted therapeuticsAlgorithmic strategiesCohortProbability thresholdScreeningClinical featuresValidation cohortElevated lipoproteinRisk inspectionARICLp(a
2019
Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis
Antonopoulos AS, Odutayo A, Oikonomou EK, Trivella M, Petrou M, Collins GS, Antoniades C, group S, Akoumianakis I, Channon K, Herdman L, Margaritis M, Neubauer S, Thomas S, Fremes S, Karkhanis R, Rade J, Fukui T, Nishida H, Takanashi S, Hwang H, Kim K, Mannacio L, Mannacio V, Nakano J, Perrault L, Kardos A, Okabayashi H, Tousoulis D, Kelion A, Sabharwal N, Krasopoulos G, Sayeed R, Taggart D. Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis. Journal Of Thoracic And Cardiovascular Surgery 2019, 160: 116-127.e4. PMID: 31606176, PMCID: PMC7322547, DOI: 10.1016/j.jtcvs.2019.07.086.Peer-Reviewed Original ResearchConceptsEarly SVG occlusionIndividual patient dataSVG occlusionRisk scoreValidation cohortEarly saphenous vein graft failureEarly saphenous vein graft occlusionSaphenous vein graft failureSaphenous vein graft occlusionAggressive treatment strategiesPatient dataVein graft occlusionNovel risk scoreVein graft failureRisk score systemGraft failureGraft occlusionOperative characteristicsTreatment strategiesIndividualized riskOperative factorsScore systemOcclusionExternal validationCohort