2021
Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score)
Oikonomou E, Schottlander D, Antonopoulos A, Marwan M, Kotanidis C, Kluner L, Shirodaria C, Channon K, Neubauer S, Desai M, Deanfield J, Achenbach S, Antoniades C. Standardised quantification of coronary inflammation using cardiac computed tomography: The Fat Attenuation Index Score (FAI-Score). European Journal Of Preventive Cardiology 2021, 28: zwab061.451. DOI: 10.1093/eurjpc/zwab061.451.Peer-Reviewed Original ResearchCoronary inflammationRight coronaryFAI scoreCardiac mortalityPercentile curvesPrognostic valueCoronary artery disease indexHigh-risk plaque featuresCardiovascular prevention strategiesTraditional risk factorsCardiac computed tomographyBritish Heart FoundationFAI valuesMedian followInflammatory burdenCardiovascular riskAtherosclerotic changesCardiac deathAnterior descendingCircumflex arteryCoronary territoriesRisk stratificationPlaque featuresCoronary arteryMean age
2020
A novel arterial redox-specific machine learning-derived radiomic signature of perivascular adipose tissue predicts cardiac mortality from routine CCTA
Kotanidis C, Akawi N, Thomas S, Siddique M, Oikonomou E, Alashi A, Akoumianakis I, Antonopoulos A, Krasopoulos G, Sayeed R, Neubauer S, Channon K, Desai M, Antoniades C. A novel arterial redox-specific machine learning-derived radiomic signature of perivascular adipose tissue predicts cardiac mortality from routine CCTA. European Heart Journal 2020, 41: ehaa946.1372. DOI: 10.1093/ehjci/ehaa946.1372.Peer-Reviewed Original ResearchArterial oxidative stressMajor adverse cardiovascular eventsVascular redox stateInternal mammary arteryVascular oxidative stressCardiac riskArm 2Radiomics signatureOxidative stressArm 3Arm 1High-risk plaque featuresEpicardial adipose tissue volumeFat attenuation indexFuture cardiac riskRadiomic featuresAdverse cardiovascular eventsPerivascular adipose tissueCardiac risk predictionAdipose tissue volumeBritish Heart FoundationLucigenin-enhanced chemiluminescenceEx vivo quantificationLong-term riskAdipose tissue compositionDirect effects of canagliflozin on human myocardial redox signalling: a novel role for SGLT1 inhibition
Kondo H, Akoumianakis I, Akawi N, Kotanidis C, Antonopoulos A, Carena M, Badi I, Oikonomou E, Reus E, Krasopoulos G, Chuaiphichai S, Shirodaria C, Channon K, Casadei B, Antoniades C. Direct effects of canagliflozin on human myocardial redox signalling: a novel role for SGLT1 inhibition. European Heart Journal 2020, 41: ehaa946.3351. DOI: 10.1093/ehjci/ehaa946.3351.Peer-Reviewed Original ResearchHuman primary cardiomyocytesNitric oxide synthaseMyocardial biopsiesHuman myocardial biopsiesMyocardial redoxOxide synthaseHuman myocardiumSodium-glucose cotransporter 2 inhibitorsMyocardial NADPH oxidase activityRight atrial appendage biopsiesGlucose cotransporter 2 inhibitorsUncoupled nitric oxide synthaseSGLT1/SGLT2 inhibitorsCotransporter 2 inhibitorsEffects of canagliflozinHeart failure patientsPro-fibrotic markersRecent clinical trialsBritish Heart FoundationNADPH oxidase subunitsBioavailability of tetrahydrobiopterinNADPH oxidase activityAnti-apoptotic effectsDirect effectBasal O2Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography
Kotanidis C, Oikonomou E, Williams M, Thomas S, Thomas K, Lyasheva M, Antonopoulos A, Dweck M, Shirodaria C, Neubauer S, Channon K, Newby D, Antoniades C. Pericoronary fat radiomic profile (FRP) predicts long-term cardiac risk in individuals with calcium score below 100 on coronary computed tomography angiography. European Heart Journal 2020, 41: ehaa946.0181. DOI: 10.1093/ehjci/ehaa946.0181.Peer-Reviewed Original ResearchCoronary artery calciumCoronary artery diseaseHigh-risk plaquesAdipose tissue compositionArtery calciumCAC scoreCardiac riskTomography angiographyStudy populationLong-term cardiac riskMajor adverse cardiac eventsObstructive coronary artery diseaseSCOT-HEART trialAdverse cardiac eventsRisk of MACEAdverse clinical eventsTraditional risk factorsChronic vascular inflammationLow CAC scoresPericoronary adipose tissueCardiovascular risk assessmentLow-risk populationCox regression modelBritish Heart FoundationBiomedical Research Centre