Featured Publications
The role of adipose tissue in cardiovascular health and disease
Oikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nature Reviews Cardiology 2018, 16: 83-99. PMID: 30287946, DOI: 10.1038/s41569-018-0097-6.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAdipose tissueCardiovascular systemCardiovascular healthInsulin resistance leadPro-atherogenic profileCardiovascular risk stratificationAdipose tissue functionAdipose tissue biologyComplex homeostatic mechanismsRisk stratificationLocal inflammationCardiovascular diseasePossible clinical translationParacrine effectsTherapeutic targetingHomeostatic mechanismsDiseaseGaseous messengerTissueClinical translationTissue biologyTissue functionCrucial regulatorCurrent knowledgeHealth
2021
Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography
Klüner LV, Oikonomou EK, Antoniades C. Assessing Cardiovascular Risk by Using the Fat Attenuation Index in Coronary CT Angiography. Radiology Cardiothoracic Imaging 2021, 3: e200563. PMID: 33778665, PMCID: PMC7977699, DOI: 10.1148/ryct.2021200563.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPerivascular adipose tissueFat attenuation indexCoronary CT angiographyCoronary inflammationPrognostic valueHigh-risk plaque featuresCoronary Artery Disease ReportingAnti-inflammatory interventionsTraditional risk factorsFirst-line diagnostic testSignificant prognostic valueChest painDisease activityCoronary atherosclerosisSecondary preventionPlaque featuresCCTA analysisCoronary arteryCoronary calciumRisk factorsObservational studyRisk discriminationCT angiographyAdipose tissueInflammation
2019
Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C. Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases. Science Translational Medicine 2019, 11 PMID: 31534019, PMCID: PMC7212031, DOI: 10.1126/scitranslmed.aav5055.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdipose TissueAnimalsArteriesAtherosclerosisBlood VesselsCell MovementEndopeptidasesEnzyme ActivationLigandsMice, Inbred C57BLMuscle, Smooth, VascularMyocytes, Smooth MuscleNADPH OxidasesObesityOxidantsOxidation-ReductionRac1 GTP-Binding ProteinSignal TransductionVascular DiseasesWnt-5a ProteinConceptsAdipose tissueArterial wallFrizzled-related protein 5Oxidative stressArterial oxidative stressVascular disease pathogenesisNADPH oxidaseCoronary plaque progressionCoronary artery diseaseVascular oxidative stressVascular smooth muscle cellsFrizzled-2Smooth muscle cellsVascular redoxArtery diseaseHuman arterial wallPlasma concentrationsPlaque progressionParacrine mechanismsObesityParacrine effectsDisease pathogenesisMuscle cellsTranslational implicationsVascular signaling
2018
Perivascular adipose tissue and coronary atherosclerosis
Mancio J, Oikonomou EK, Antoniades C. Perivascular adipose tissue and coronary atherosclerosis. Heart 2018, 104: 1654. PMID: 29853488, DOI: 10.1136/heartjnl-2017-312324.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic risk profilePerivascular ATPerivascular adipose tissueAdipose tissueCardiovascular diseaseVascular wallEpicardial adipose tissueClose anatomical proximityAnti-atherogenic rolePotential therapeutic targetNovel clinical diagnostic toolsPromising new modalityCoronary inflammationCoronary atherosclerosisInflammatory statusNon-invasive imagingCardiovascular healthBody of evidenceAnatomical proximityCurrent evidenceTherapeutic targetAdjacent vasculatureClinical diagnostic toolRisk profileTherapeutic opportunities
2017
Immunometabolic Regulation of Vascular Redox State: The Role of Adipose Tissue
Oikonomou EK, Antoniades C. Immunometabolic Regulation of Vascular Redox State: The Role of Adipose Tissue. Antioxidants & Redox Signaling 2017, 29: 313-336. PMID: 28657335, DOI: 10.1089/ars.2017.7017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements