2023
Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample
Cunha G, Caye A, Pan P, Fisher H, Pereira R, Ziebold C, Bressan R, Miguel E, Salum G, Rohde L, Kohrt B, Mondelli V, Kieling C, Gadelha A. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Brazilian Journal Of Psychiatry 2023, 45: 242-248. PMID: 37126861, PMCID: PMC10288471, DOI: 10.1590/1516-4446-2022-2775.Peer-Reviewed Original Research
2019
Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity
de Oliveira Santos B, Gorgulho A, Saraiva C, Lopes A, Gomes J, Pássaro A, Hoexter M, Miguel E, De Salles A. Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity. Surgical Neurology International 2019, 10: 136. PMID: 31528471, PMCID: PMC6744751, DOI: 10.25259/sni-65-2019.Peer-Reviewed Original ResearchDiffusion tensor image tractographyMorbid obesity patientsOCD patientsObesity patientsInternal capsuleOrbitofrontal cortexAnterior internal capsuleGamma ventral capsulotomyMedial orbitofrontal cortexFunctional stereotactic proceduresFunctional patientsMorbid obesityMean ageTract fibersAnterior limbCerebral hemispheresPatientsFiber tractsDisorder individualsStereotactic proceduresDeep brain stimulation implantsObesityTractography parametersExact topographyTractography
2016
Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis
Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI, Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP, Giménez M, Gruner P, Hanna GL, Hibar DP, Hoexter MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón JM, Minuzzi L, Nakamae T, Nakao T, Narayanaswamy JC, Piras F, Piras F, Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson P, Stein D, van den Heuvel O, Abe Y, Alonso P, Ameis S, Arnold P, Bargalló N, Batistuzzo M, Benedetti F, Beucke J, Boedhoe P, Bollettini I, Bose A, Brem S, Busatto G, Calvo A, Calvo R, Cath D, Cheng Y, Cho K, Dallaspezia S, de Vries F, de Wit S, Denys D, Fang Y, Fitzgerald K, Fontaine M, Fouche J, Giménez M, Gruner P, Hanna G, Hibar D, Hoexter M, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann N, Kaufmann C, Khadka S, Koch K, Kwon J, Lazaro L, Liu Y, Lochner C, Marsh R, Martínez-Zalacaín I, Mataix-Cols D, Menchón J, Miguel E, Minuzzii L, Morer A, Nakamae T, Nakao T, Narayanaswamy J, Piras F, Piras F, Pittenger C, Reddy Y, Sato J, Simpson H, Schmaal L, Soreni N, Soriano-Mas C, Spalletta G, Stein D, Stevens M, Szeszko P, Thompson P, Tolin D, Veltman D, Venkatasubramanian G, van den Heuvel O, van der Werf Y, van Wingen G, Walitza S, Wang Z, Xu J, Xu X, Yun J, Zhao Q. Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis. American Journal Of Psychiatry 2016, 174: 60-69. PMID: 27609241, PMCID: PMC5344782, DOI: 10.1176/appi.ajp.2016.16020201.Peer-Reviewed Original ResearchConceptsAdult obsessive-compulsive disorderObsessive-compulsive disorderOCD patientsLarger thalamic volumesSubcortical volume alterationsSmaller hippocampal volumesAdult OCD patientsPediatric obsessive-compulsive disorderPotential modulating effectSubcortical brain volumesLimited statistical powerPallidum volumeClinical characteristicsAdult patientsPediatric patientsMean ageThalamic volumeControl subjectsPediatric controlsSubcortical abnormalitiesIllness profileHippocampal volumeHealthy subjectsNeurodevelopmental alterationsPatients
2013
Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder
Torresan R, Ramos-Cerqueira A, Shavitt R, do Rosário M, de Mathis M, Miguel E, Torres A. Symptom dimensions, clinical course and comorbidity in men and women with obsessive-compulsive disorder. Psychiatry Research 2013, 209: 186-195. PMID: 23298952, DOI: 10.1016/j.psychres.2012.12.006.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderClinical courseComorbid post-traumatic stress disorderDSM-IV Axis ICross-sectional studyStructured Clinical InterviewAlcohol use disorderSymptom dimensionsPost-traumatic stress disorderAdult OCD patientsBrazilian Research ConsortiumYale-Brown ObsessiveFemale patientsClinical presentationMean ageSymptom interferenceObsessive-compulsive spectrum disordersMajor depressionTic disordersFemale genderAxis IUse disordersClinical InterviewAnorexia nervosaSkin picking2711 – Trajectory of comorbidity in obsessive-compulsive disorder
de Mathis A, Diniz J, Shavitt R, do Rosário M, Miguel E. 2711 – Trajectory of comorbidity in obsessive-compulsive disorder. European Psychiatry 2013, 28: 1. DOI: 10.1016/s0924-9338(13)77321-8.Peer-Reviewed Original ResearchComorbid psychiatric disordersFirst diagnosisPsychiatric disordersOCD patientsAnxiety disordersMain psychiatric diagnosisPost-traumatic stress disorderClinical manifestationsComorbid schizophreniaMean ageObsessive-compulsive disorderTic disordersSeparation anxiety disorderSomatoform disordersComorbid disordersPsychiatric diagnosisPanic disorderPatientsSubstance abuseSimple phobiaStress disorderHigh frequencyOCD outpatientsDiagnosisDisorders
2012
Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study
de Alvarenga P, de Mathis M, Alves A, do Rosário M, Fossaluza V, Hounie A, Miguel E, Torres A. Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study. CNS Spectrums 2012, 17: 87-93. PMID: 22789066, DOI: 10.1017/s1092852912000491.Peer-Reviewed Original ResearchConceptsYale Global Tic Severity ScaleTic disordersComorbid tic disordersYale-Brown ObsessiveClinical featuresAnxiety disordersChronic vocal tic disorderDSM-IV Axis I DisordersTic-related obsessive-compulsive disorderChronic motor tic disorderCompulsive ScaleVocal tic disorderMotor tic disorderLarge multicenter studyCross-sectional studyStructured Clinical InterviewAxis I DisordersTic Severity ScaleObsessive-compulsive disorder patientsPost-traumatic stress disorderAttention deficit hyperactivity disorderSensory phenomenaSymptom onsetMulticenter studyMean age
2008
Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil
Torresan R, de Abreu Ramos-Cerqueira A, de Mathis M, Diniz J, Ferrão Y, Miguel E, Torres A. Sex differences in the phenotypic expression of obsessive-compulsive disorder: an exploratory study from Brazil. Comprehensive Psychiatry 2008, 50: 63-69. PMID: 19059516, DOI: 10.1016/j.comppsych.2008.05.005.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderObsessive-compulsive symptomsBeck DepressionYale Global Tic Severity ScaleComorbid simple phobiasFemale Brazilian patientsStructured Clinical InterviewPrivate practice clinicTic Severity ScaleAnxiety InventoryComorbid tic disordersEfficacious treatment approachGlobal symptom severityPosttraumatic stress disorderSex-related differencesYale-Brown ObsessiveClinical characteristicsClinical featuresMean agePsychiatric comorbiditySymptom interferencePractice clinicsTic disordersBrazilian patientsFamily history
2005
A family study of early‐onset obsessive‐compulsive disorder
do Rosario‐Campos M, Leckman JF, Curi M, Quatrano S, Katsovitch L, Miguel EC, Pauls DL. A family study of early‐onset obsessive‐compulsive disorder. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2005, 136B: 92-97. PMID: 15892140, DOI: 10.1002/ajmg.b.30149.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderRecurrence riskChronic ticsFirst-degree family membersChildhood-onset obsessive-compulsive disorderDiagnosis of OCDChronic tic disorderStandardized semi-structured interviewFirst-degree relativesEarly-onset casesOnset obsessive-compulsive disorderDSM-IV criteriaEarly-onset obsessive-compulsive disorderBest-estimate processRandom digit dialingHigh comorbid ratesAge of onsetFamily studiesHigh genetic loadingMean ageSpecialty clinicTic disordersComorbid ratesValid subgroupsCase relatives