Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene
Park E, Choi S, Kim J, Jeong Y, Choe J, Park C, Choi Y, Rho J. Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. Biochemical And Biophysical Research Communications 2007, 363: 971-977. PMID: 17927961, DOI: 10.1016/j.bbrc.2007.09.103.Peer-Reviewed Original ResearchConceptsTumor necrosis factor receptor (TNFR)-associated factorsTRAF-interacting proteinCylindromatosis tumor suppressor geneFamilial cylindromatosis tumour suppressor geneHomozygous mouse embryosComplex in vitroEarly embryonic lethalityTumor suppressor geneExcessive cell deathNF-kappaB signalingAdaptor moleculeEmbryonic lethalityProliferation defectEmbryonic development in vivoSignaling in vitroSuppressor geneSignaling cascadesCell deathActivity in vitroDevelopment in vivoTargeted disruptionNF-kappaB activation in vitroFunctional roleCell proliferationMouse embryos