2023
PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
Xu D, Jiang W, Wu L, Gaudet R, Park E, Su M, Cheppali S, Cheemarla N, Kumar P, Uchil P, Grover J, Foxman E, Brown C, Stansfeld P, Bewersdorf J, Mothes W, Karatekin E, Wilen C, MacMicking J. PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection. Nature 2023, 619: 819-827. PMID: 37438530, PMCID: PMC10371867, DOI: 10.1038/s41586-023-06322-y.Peer-Reviewed Original ResearchConceptsC-terminal β-barrel domainSpike-mediated fusionCell-autonomous defenseLarge-scale exome sequencingΒ-barrel domainGenome-wide CRISPRSARS-CoV-2 infectionHost cell cytosolScramblase activityPhospholipid scramblaseLive SARS-CoV-2 infectionHuman lung epitheliumPLSCR1SARS-CoV-2 USASingle-molecule switchingSARS-CoV-2 variantsExome sequencingHuman populationRestriction factorsViral RNANew SARS-CoV-2 variantsSARS-CoV-2Robust activityLung epitheliumDefense factors
2016
Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus
Kamau A, Park J, Park E, Yu J, Rho J, Shin H. Porcine amino peptidase N domain VII has critical role in binding and entry of porcine epidemic diarrhea virus. Virus Research 2016, 227: 150-157. PMID: 27732876, PMCID: PMC7114530, DOI: 10.1016/j.virusres.2016.10.004.Peer-Reviewed Original ResearchConceptsPorcine aminopeptidase NPorcine epidemic diarrhea virusNIH3T3 cellsDomain VIIDiarrhea virusPorcine epidemic diarrhea virus infectionDeletion mutantsMutantsEnteric diseaseDomain IIIIntestinal cellsVero cellsAminopeptidase NTime course testIndirect plaquesTherapeutic developmentCellsBindingPorcineVirus