2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2012
D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1
Yu J, Choi S, Park E, Shin B, Yu J, Lee S, Takami M, Kang J, Meong H, Rho J. D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. Journal Of Clinical Immunology 2012, 32: 1360-1371. PMID: 22711011, DOI: 10.1007/s10875-012-9722-z.Peer-Reviewed Original ResearchConceptsTartrate-resistant acid phosphataseEffect of D-chiro-inositolOC differentiationD-chiro-inositolExpression of OC marker genesNuclear factor of activated T cells c1Inflammatory bone lossCell-cell fusionAccelerated bone destructionDose-dependent mannerExpression of NFATc1Formation of multinucleated osteoclastsBone-related diseasesMultinucleated giant cellsSecondary osteoporosisCell fusion assayOsteoclastogenic genesBone destructionBone lossDiabetes mellitusOC precursorsGiant cellsOC formationMultinucleated osteoclastsNFATc1