2021
Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Kim H, Lee K, Kim J, Kim M, Kim J, Lee H, Chung Y, Shin H, Kim T, Park E, Rho J, Lee S, Kim N, Lee S, Choi Y, Jeong D. Selenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts. Nature Communications 2021, 12: 2258. PMID: 33859201, PMCID: PMC8050258, DOI: 10.1038/s41467-021-22565-7.Peer-Reviewed Original ResearchConceptsSelenoprotein WCell-cell fusionRNA sequencing analysisProfile of receptor activationOsteoclast differentiationNuclear factor of activated T cells cytoplasmic 1Bone remodelingBone mass phenotypeOsteoclastogenesis in vitroNuclear translocation of NF-kBTranslocation of NF-kBPhysiological bone remodelingBlocks osteoporosisNuclear translocationNuclear factorOsteoclastogenic genesMechanism of actionMass phenotypeBone metabolismBone resorptionReceptor activationOsteoclast maturationCytoplasmic 1Osteoclast formationNF-kB
2014
Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*
Shin B, Yu J, Park E, Choi S, Yu J, Hwang J, Yun H, Chung Y, Hong K, Choi J, Takami M, Rho J. Secretion of a Truncated Osteopetrosis-associated Transmembrane Protein 1 (OSTM1) Mutant Inhibits Osteoclastogenesis through Down-regulation of the B Lymphocyte-induced Maturation Protein 1 (BLIMP1)-Nuclear Factor of Activated T Cells c1 (NFATc1) Axis*. Journal Of Biological Chemistry 2014, 289: 35868-35881. PMID: 25359771, PMCID: PMC4276856, DOI: 10.1074/jbc.m114.589614.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone ResorptionCell DifferentiationCell FusionCell SurvivalCells, CulturedDown-RegulationGene ExpressionLipopolysaccharidesMaleMembrane ProteinsMice, Inbred C57BLNFATC Transcription FactorsOsteoclastsOsteoporosisPositive Regulatory Domain I-Binding Factor 1Signal TransductionTranscription FactorsConceptsSecreted formTransmembrane domainOsteopetrosis-associated transmembrane protein 1Down-regulationAutosomal recessive osteopetrosis patientsTransmembrane protein 1Marker genesCell surfaceActivated T cells c1Genetic defectsExpression of OC marker genesCell fusionFunctional roleGenetic mutationsAutosomal recessive osteopetrosisMutationsProtein 1Bone destruction in vivoGene mutationsGenesDestruction in vivoRecessive osteopetrosisOsteoclast (OCOsteopetrosis patientsOsteoclastogenic genes
2012
D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1
Yu J, Choi S, Park E, Shin B, Yu J, Lee S, Takami M, Kang J, Meong H, Rho J. D-chiro-inositol Negatively Regulates the Formation of Multinucleated Osteoclasts by Down-Regulating NFATc1. Journal Of Clinical Immunology 2012, 32: 1360-1371. PMID: 22711011, DOI: 10.1007/s10875-012-9722-z.Peer-Reviewed Original ResearchConceptsTartrate-resistant acid phosphataseEffect of D-chiro-inositolOC differentiationD-chiro-inositolExpression of OC marker genesNuclear factor of activated T cells c1Inflammatory bone lossCell-cell fusionAccelerated bone destructionDose-dependent mannerExpression of NFATc1Formation of multinucleated osteoclastsBone-related diseasesMultinucleated giant cellsSecondary osteoporosisCell fusion assayOsteoclastogenic genesBone destructionBone lossDiabetes mellitusOC precursorsGiant cellsOC formationMultinucleated osteoclastsNFATc1