Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*
Yu J, Yun H, Shin B, Kim Y, Park E, Choi S, Yu J, Amarasekara D, Kim S, Inoue J, Walsh M, Choi Y, Takami M, Rho J. Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis*. Journal Of Biological Chemistry 2016, 291: 20643-20660. PMID: 27507811, PMCID: PMC5034056, DOI: 10.1074/jbc.m116.728303.Peer-Reviewed Original ResearchConceptsTNF receptor-associated factor 6Signaling complexIVVY motifCross-talkDbl homology domainCoiled-coil domainFactor 6RANK-mediated osteoclastogenesisTRAF6-binding siteFunctional cross-talkUbiquitin pathwayBinding partnersCytoplasmic tailTumor necrosis factor receptor-associated factor 6Activation of nuclear factor-kBInteraction partnersNuclear factor-kBProteomic approachVav3Signaling cascadesFunctional importanceMotifCooperative signalingMutantsInteraction of tumor necrosis factor receptor-associated factor 6