The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature.
Fortier M, Caron E, Hardy M, Voisin G, Lemieux S, Perreault C, Thibault P. The MHC I Immunopeptidome Is Moulded by the Transcriptome and Conceals a Tissue-Specific Signature. Blood 2007, 110: 1327. DOI: 10.1182/blood.v110.11.1327.1327.Peer-Reviewed Original ResearchSource mRNATissue-specific signaturesBiological replicatesPrimary mouse thymocytesEL4 cellsNeoplastic transformationRelative quantificationCancer cellsRelative expressionExpression ratioMass spectrometry approachMRNA levelsAbundant transcriptsTranscriptomic dataHigh-throughput analysisMHC IPosttranscriptional mechanismsNeoplastic thymocytesSurvival signalsNormal thymocytesSource proteinsRelative abundanceIntracellular pathogensSpearman correlation coefficientNeoplastic cells