2024
Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells.
Verma S, Bradley M, Gray J, Dogra P, Caron D, Maurrasse S, Grunstein E, Waldman E, Jang M, Pethe K, Farber D, Connors T. Distinct Localization, Transcriptional Profiles, and Functionality in Early Life Tonsil Regulatory T Cells. The Journal Of Immunology 2024, 213: 306-316. PMID: 38905110, PMCID: PMC11304551, DOI: 10.4049/jimmunol.2300890.Peer-Reviewed Original ResearchRegulatory T cellsT cellsTreg biologyCD4+ regulatory T cellsCD8+ T cellsIncreased Foxp3 expressionProportion of TregsProduction of IL-10Paired blood samplesHigher proliferative capacityTranscriptional profilesAdult TregsTreg activityFoxp3 expressionTreg identityExtrafollicular regionsTregsIL-10Primary siteProtective immunityProliferative capacityImmune responseImmunological developmentAdult subjectsImmune system
2021
Signature of Enhanced Effector Function Defines Early Life Regulatory T Cells
Connors T, Bradley M, Verma S, Waldman E, Jang M, Grunstein E, Maurrasse S, Pethe K, Dogra P, Farber D. Signature of Enhanced Effector Function Defines Early Life Regulatory T Cells. The Journal Of Immunology 2021, 206: 98.27-98.27. DOI: 10.4049/jimmunol.206.supp.98.27.Peer-Reviewed Original ResearchRegulatory T cellsT cellsImmune responseEarly lifeGut-specific homingPrimary antigenic challengeIntestinal immune homeostasisConventional T cellsPotential effector mechanismsInflammatory immune responseEnhanced effector functionMulti-parameter flow cytometryAdult TregsImmunosuppressive mechanismsAntigenic challengeImmune homeostasisEffector mechanismsTregsImmune developmentEffector functionsSuppressive functionImmunological challengeHigh proliferative capacityCell cycleBulk RNA sequencing