2018
Life's Simple 7 and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis
Ogunmoroti O, Michos ED, Aronis KN, Salami JA, Blankstein R, Virani SS, Spatz ES, Allen NB, Rana JS, Blumenthal RS, Veledar E, Szklo M, Blaha MJ, Nasir K. Life's Simple 7 and the risk of atrial fibrillation: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2018, 275: 174-181. PMID: 29920438, DOI: 10.1016/j.atherosclerosis.2018.05.050.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAtrial FibrillationBlood GlucoseBlood PressureBody Mass IndexDiet, HealthyExerciseFemaleHealth StatusHealthy LifestyleHumansIncidenceLipidsMaleMiddle AgedPrimary PreventionProspective StudiesProtective FactorsRisk AssessmentRisk FactorsRisk Reduction BehaviorSmokingTime FactorsUnited StatesConceptsAtrial fibrillationMulti-Ethnic StudyRace/ethnicityHazard ratioOverall cohortSimple 7Cardiovascular healthCardiovascular diseaseLower riskAmerican Heart Association's LifeBurden of AFFirst AF episodeSimple 7 (LS7) metricsIdeal cardiovascular healthProportional hazard ratiosProspective cohort studyLife's Simple 7Hospital discharge recordsICD-9 codesLS7 metricsCohort studyIncidence rateAF episodesInadequate scoresAssociation's Life
2017
Life's Simple 7 and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis
Ogunmoroti O, Oni E, Michos ED, Spatz ES, Allen NB, Rana JS, Virani SS, Blankstein R, Aronis KN, Blumenthal RS, Veledar E, Szklo M, Blaha MJ, Nasir K. Life's Simple 7 and Incident Heart Failure: The Multi‐Ethnic Study of Atherosclerosis. Journal Of The American Heart Association 2017, 6: e005180. PMID: 28655734, PMCID: PMC5669160, DOI: 10.1161/jaha.116.005180.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBiomarkersBlood GlucoseBlood PressureBody Mass IndexCholesterolDiet, HealthyExerciseFemaleHealthy LifestyleHeart FailureHumansIncidenceKaplan-Meier EstimateMaleMiddle AgedPrognosisProtective FactorsRisk FactorsRisk Reduction BehaviorSmoking CessationTime FactorsUnited StatesConceptsSimple 7 (LS7) metricsIncident heart failureHeart failureMulti-Ethnic StudyLS7 metricsHazard ratioSimple 7Cardiovascular healthBurden of HFLife's Simple 7 (LS7) metricsIncidence of HFIdeal cardiovascular healthProportional hazard ratiosLife's Simple 7American Heart AssociationRace/ethnicityLS7 scoreHeart AssociationIncidence rateCardiovascular diseaseMultiethnic cohortLower riskInadequate scoresIdeal metricsAtherosclerosisHIV/HCV coinfection and the risk of cardiovascular disease: A meta‐analysis
Osibogun O, Ogunmoroti O, Michos E, Spatz E, Olubajo B, Nasir K, Madhivanan P, Maziak W. HIV/HCV coinfection and the risk of cardiovascular disease: A meta‐analysis. Journal Of Viral Hepatitis 2017, 24: 998-1004. PMID: 28502092, DOI: 10.1111/jvh.12725.Peer-Reviewed Original ResearchConceptsHIV/HCV coinfectionHCV coinfectionHazard ratioCardiovascular diseaseHIV monoinfectionCVD riskHepatitis C virus coinfectionTraditional CVD risk factorsC virus coinfectionImproved antiretroviral therapyAdjusted hazard ratioCVD risk factorsRisk reduction therapyCongestive heart failureCoronary artery diseaseHuman immunodeficiency virusIncreased inflammatory responseRandom-effects modelWeb of ScienceHCV individualsAntiretroviral therapyCohort studyCVD outcomesArtery diseaseHeart failureHeterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)
Dhruva SS, Huang C, Spatz ES, Coppi AC, Warner F, Li SX, Lin H, Xu X, Furberg CD, Davis BR, Pressel SL, Coifman RR, Krumholz HM. Heterogeneity in Early Responses in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). Hypertension 2017, 70: 94-102. PMID: 28559399, DOI: 10.1161/hypertensionaha.117.09221.Peer-Reviewed Original ResearchConceptsAntihypertensive therapySystolic blood pressure responseAdverse cardiovascular eventsFavorable initial responseBlood pressure responseHigher hazard ratioCardiovascular eventsCardiovascular outcomesHazard ratioMultivariable adjustmentHeart failureAverage SBPRandomized trialsOdds ratioCardiovascular diseaseSBPStudy participantsRespondersMonthsPressure responseImmediate respondersALLHATEarly responseInitial responseSuperior discrimination
2016
Diabetes Mellitus and Outcomes of Cardiac Resynchronization With Implantable Cardioverter-Defibrillator Therapy in Older Patients With Heart Failure
Echouffo-Tcheugui JB, Masoudi FA, Bao H, Spatz ES, Fonarow GC. Diabetes Mellitus and Outcomes of Cardiac Resynchronization With Implantable Cardioverter-Defibrillator Therapy in Older Patients With Heart Failure. Circulation Arrhythmia And Electrophysiology 2016, 9: e004132. PMID: 27489243, DOI: 10.1161/circep.116.004132.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyDevice-related complicationsDiabetes mellitusResynchronization therapyHeart failureHazard ratioOlder patientsHigh riskHeart failure-related readmissionsImplantable Cardioverter-Defibrillator RegistryImplantable cardioverter-defibrillator therapyNational Cardiovascular Data RegistryDiabetes mellitus statusCardioverter-defibrillator therapyCause readmissionMellitus statusDefibrillator implantationRenal failureProcedural complicationsCardiac resynchronizationDevice implantationQRS durationOdds ratioMellitusSimilar risk
2014
Sex-Specific Mortality Risk by QRS Morphology and Duration in Patients Receiving CRT Results From the NCDR
Zusterzeel R, Curtis JP, Caños DA, Sanders WE, Selzman KA, Piña IL, Spatz ES, Bao H, Ponirakis A, Varosy PD, Masoudi FA, Strauss DG. Sex-Specific Mortality Risk by QRS Morphology and Duration in Patients Receiving CRT Results From the NCDR. Journal Of The American College Of Cardiology 2014, 64: 887-894. PMID: 25169173, DOI: 10.1016/j.jacc.2014.06.1162.Peer-Reviewed Original ResearchConceptsLeft bundle branch blockNational Cardiovascular Data RegistryLonger QRS durationQRS durationQRS morphologyHazard ratioMortality riskBetter survivalCardiac resynchronization therapy defibrillator implantationImplantable Cardioverter-Defibrillator RegistrySex-specific mortality risksCRT-D implantationCRT-D patientsBundle branch blockLower mortality riskSex differencesComparator groupBranch blockData registryBetter outcomesPatientsLower mortalitySurvival curvesMortalityWomen