2023
Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates
Chang Y, Lin C, Chen C, Hwang E, Alshetaili A, Yu H, Fang J. Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates. Acta Biomaterialia 2023, 174: 331-344. PMID: 38061677, DOI: 10.1016/j.actbio.2023.11.040.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureus infectionIntracellular bacterial countsMouse bacteremia modelBacteremia modelSurvival rateEffective treatmentInhibition of cytokine releaseMedian survival timeDecreased neutrophil activationImproved survival ratesOrgan distributionIncreased survival rateMRSA coloniesAntibody-conjugated nanoparticlesMRSA burdenOrgan dysfunctionCytokine releaseLy6GCytokine/chemokine releaseProlonged circulationPeripheral organsTargeted nanoparticlesFree drugSurvival time
2022
The role of cytokines/chemokines in an aging skin immune microenvironment
Lin Z, Hsu C, Hwang E, Wang P, Fang J. The role of cytokines/chemokines in an aging skin immune microenvironment. Mechanisms Of Ageing And Development 2022, 210: 111761. PMID: 36496171, DOI: 10.1016/j.mad.2022.111761.Peer-Reviewed Original ResearchConceptsCytokines/chemokinesCutaneous barrier functionTransepidermal water lossLoss of elasticityImmune environmentImmune microenvironmentImmune cellsLifestyle habitsImmunological perspectiveEpidermal thinningImmune systemOverall healthChemokinesBarrier functionSkin agingIndividual exposurePhysiological declineCell-cell crosstalkSkinCytokinesIndividual healthHost cellsHealthCellsExposure