Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates
Chang Y, Lin C, Chen C, Hwang E, Alshetaili A, Yu H, Fang J. Neutrophil-targeted combinatorial nanosystems for suppressing bacteremia-associated hyperinflammation and MRSA infection to improve survival rates. Acta Biomaterialia 2023, 174: 331-344. PMID: 38061677, DOI: 10.1016/j.actbio.2023.11.040.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-resistant Staphylococcus aureus infectionIntracellular bacterial countsMouse bacteremia modelBacteremia modelSurvival rateEffective treatmentInhibition of cytokine releaseMedian survival timeDecreased neutrophil activationImproved survival ratesOrgan distributionIncreased survival rateMRSA coloniesAntibody-conjugated nanoparticlesMRSA burdenOrgan dysfunctionCytokine releaseLy6GCytokine/chemokine releaseProlonged circulationPeripheral organsTargeted nanoparticlesFree drugSurvival time