Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect
Hsu C, Liao C, Lin Z, Alalaiwe A, Hwang E, Lin T, Fang J. Facile adipocyte uptake and liver/adipose tissue delivery of conjugated linoleic acid-loaded tocol nanocarriers for a synergistic anti-adipogenesis effect. Journal Of Nanobiotechnology 2024, 22: 50. PMID: 38317220, PMCID: PMC10845550, DOI: 10.1186/s12951-024-02316-8.Peer-Reviewed Original ResearchConceptsAcetyl-CoA carboxylaseFatty acid synthaseAnti-adipogenesis effectConjugated linoleic acidLipogenic enzymes acetyl-CoA carboxylaseEnzyme acetyl-CoA carboxylaseNanostructured lipid carriersIn vitro adipocyte modelsAnti-adipogenic activityAcid synthaseAdipogenesis inhibitionAdipocyte modelInhibit adipogenesisAdipose tissueAdipocytesAdipogenesisAdipocyte hypertrophyIn vivo rat modelLipid-based nanocarriersA-tocopherolReduced body weightObese ratsRat modelTotal cholesterolFat accumulation