2023
Studying classic psychedelics for the management of headache disorders: Considerations for Veterans
Schindler E, Sico J. Studying classic psychedelics for the management of headache disorders: Considerations for Veterans. Journal Of Military Veteran And Family Health 2023, 9: 88-95. DOI: 10.3138/jmvfh-2023-0006.Peer-Reviewed Original ResearchHeadache disordersCluster headacheLysergic acid diethylamideTreatment optionsBrain injuryTherapeutic effectAcid diethylamideTraumatic brain injuryConventional treatment optionsTrials of psilocybinMilitary membersPoor qualityPsychedelic drugsSummary PatientsHead traumaAvailable treatmentsHeadache managementHeadache treatmentCommon conditionHigh riskSide effectsSignificant disabilityHeadacheMore researchPoor efficacy
2015
Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey
Schindler EA, Gottschalk CH, Weil MJ, Shapiro RE, Wright DA, Sewell RA. Indoleamine Hallucinogens in Cluster Headache: Results of the Clusterbusters Medication Use Survey. Journal Of Psychoactive Drugs 2015, 47: 372-381. PMID: 26595349, DOI: 10.1080/02791072.2015.1107664.Peer-Reviewed Original ResearchConceptsCluster headacheIndoleamine hallucinogensConventional medicationsChronic cluster headachePain syndromePreventative medicationsAlternative medicationsLysergic acid diethylamideHeadache clinicConventional therapyCluster periodHeadacheMedicationsFinal analysisAcid diethylamideHallucinogensFurther investigationMost responsesSignificant numberAdditional evidenceParticipantsRemissionPatientsSyndromeClinic
2012
Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex
Schindler EA, Harvey JA, Aloyo VJ. Phospholipase C mediates (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-, but not lysergic acid diethylamide (LSD)-elicited head bobs in rabbit medial prefrontal cortex. Brain Research 2012, 1491: 98-108. PMID: 23123701, PMCID: PMC3559188, DOI: 10.1016/j.brainres.2012.10.057.Peer-Reviewed Original ResearchMeSH KeywordsAmphetaminesAnimalsBehavior, AnimalCerebral CortexEnzyme ActivationEnzyme InhibitorsEstrenesHallucinogensHead MovementsHydrolysisLysergic Acid DiethylamideMaleMicroinjectionsPhosphatidylinositolsPrefrontal CortexPyrrolidinonesRabbitsReceptor, Serotonin, 5-HT2ASerotonin AntagonistsSerotonin Receptor AgonistsSignal TransductionType C PhospholipasesConceptsMedial prefrontal cortexLysergic acid diethylamidePI hydrolysisReceptor antagonistPrefrontal cortexDimethoxy-4Acid diethylamidePhospholipase CDistinct pharmacological propertiesEffects of hallucinogensActivation of PLCTissue prismsSerotonergic receptorsReceptor mechanismsPhosphatidylinositol hydrolysisPharmacological propertiesIntracellular mechanismsPLC inhibitorPLC activationHead bobsTrien-17Receptor signalsHallucinogensNovel findingsAntagonist
2011
Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)
Schindler EA, Dave KD, Smolock EM, Aloyo VJ, Harvey JA. Serotonergic and dopaminergic distinctions in the behavioral pharmacology of (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Pharmacology Biochemistry And Behavior 2011, 101: 69-76. PMID: 22197710, PMCID: PMC3272148, DOI: 10.1016/j.pbb.2011.12.002.Peer-Reviewed Original ResearchConceptsHead-bobbing behaviourLysergic acid diethylamideReceptor antagonistEx vivoDimethoxy-4Acute drug injectionAcid diethylamideChronic drug treatmentBehavioral pharmacologyMechanism of actionReceptor binding propertiesDrug injectionDrug treatmentAnimal modelsReceptor activationBehavioral effectsClinical literatureReceptorsAntagonist ligandsNaïve rabbitsPharmacologyHallucinogensAntagonistAminopropaneVivo
2010
Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al.
Romano AG, Quinn JL, Li L, Dave KD, Schindler EA, Aloyo VJ, Harvey JA. Intrahippocampal LSD accelerates learning and desensitizes the 5-HT2A receptor in the rabbit, Romano et al. Psychopharmacology 2010, 212: 441-448. PMID: 20827462, DOI: 10.1007/s00213-010-2004-7.Peer-Reviewed Original ResearchConceptsDorsal hippocampusDevelopment of desensitizationD-lysergic acid diethylamideEyeblink conditioningChronic administrationAminopropane hydrochlorideLast infusionIntrahippocampal injectionReceptor agonistParenteral injectionSerotonin 5HippocampusTrace eyeblink conditioningAcid diethylamideReceptorsPavlovian conditioningConditioning sessionsVehicle controlInjectionAgonists