2024
Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review
Chowdhury S, Sirotich E, Guyatt G, Gill D, Modi D, Venier L, Mahamad S, Chowdhury M, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, ‐DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Agarwal A, Nazaryan H, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Shafiee A, Rathod P, Kwon H, Dookie J, Zeraatkar D, Thabane L, Couban R, Arnold D. Treatment of Critical Bleeds in Patients With Immune Thrombocytopenia: A Systematic Review. European Journal Of Haematology 2024 PMID: 39552264, DOI: 10.1111/ejh.14351.Peer-Reviewed Original ResearchImmune thrombocytopeniaCritical bleedingTPO-RAsPlatelet transfusionsCritically bleeding patientsPlatelet count responseSystematic reviewReview of treatmentBleeding patientsIVIGEvidence-based protocolsBleedingBleeding emergenciesCorticosteroidsSystematic review of treatmentsPatientsSplenectomyPatient outcomesIndividualized treatmentThrombocytopeniaPlateletTransfusionEffects of individual treatmentsTreatmentStudy design
2023
Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review
Sirotich E, Chowdhury S, Guyatt G, Gill D, Modi D, Venier L, Eisa K, Beck C, Breakey V, de Wit K, Porter S, Webert K, Cuker A, O'Connor C, DiRaimo J, Yan J, Manski C, Kelton J, Kang M, Strachan G, Hassan Z, Pruitt B, Pai M, Grace R, Paynter D, Charness J, Cooper N, Fein S, Nazaryan H, Agarwal A, Siddiqui I, Leong R, Pallapothu S, Wen A, Xu E, Liu B, Rathod P, Kwon H, Dookie J, Shafiee A, Couban R, Arnold D. Treatment of Critical Bleeding Events in Patients with Immune Thrombocytopenia: A Systematic Review. Blood 2023, 142: 7239. DOI: 10.1182/blood-2023-179448.Peer-Reviewed Original ResearchPlatelet count responseTPO-RAsImmune thrombocytopeniaPlatelet transfusionsCritical bleedingBleed resolutionTreated with platelet transfusionsPatients treated with splenectomyControlled trialsCritical bleeding eventsManagement of critical bleedingTPO receptor agonistsCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsSystematic reviewTreatment of critical bleedingCochrane Central RegisterReview of treatmentEvidence-based treatment protocolsClinical practice guidelinesRandomized controlled trialsCount responseIntraperitoneal bleedingOcular bleeding
2020
Management of major bleeds in patients with immune thrombocytopenia
Mithoowani S, Cervi A, Shah N, Ejaz R, Sirotich E, Barty R, Li N, Nazy I, Arnold D. Management of major bleeds in patients with immune thrombocytopenia. Journal Of Thrombosis And Haemostasis 2020, 18: 1783-1790. PMID: 32219982, DOI: 10.1111/jth.14809.Peer-Reviewed Original ResearchConceptsMajor bleedsImmune thrombocytopeniaEmergency departmentITP patientsEvidence-based treatment strategiesIntravenous immune globulinRetrospective cohort studyPermanent neurological disabilityITP therapyMajor bleedingRecurrent bleedsHemodynamic instabilityMinor bleedingCohort studyED visitsGross hematuriaImmune globulinAcute treatmentNeurological disabilityArterial thrombosisPlatelet transfusionsSevere thrombocytopeniaSignificant morbidityMale sexRisk factors