2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased risk
2022
Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
Woo E, Datta D, Arnsten AFT. Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex. Frontiers In Neuroanatomy 2022, 16: 849937. PMID: 35444520, PMCID: PMC9013768, DOI: 10.3389/fnana.2022.849937.Peer-Reviewed Original ResearchPrelimbic medial prefrontal cortexRat prelimbic medial prefrontal cortexMedial prefrontal cortexLayer IIIPrefrontal cortexDendritic spinesReceptor type 3Dorsolateral prefrontal cortexPrimate dlPFCReceptor subtypesAxon terminalsNeuronal firingPL-mPFCIntervaricose segmentsMGlu3Glial membranesRhesus monkeysPredominant locationType 3GliaCognitive functioningDLPFCCortexSpineCurrent studyUnusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia
Arnsten AFT, Woo E, Yang S, Wang M, Datta D. Unusual Molecular Regulation of Dorsolateral Prefrontal Cortex Layer III Synapses Increases Vulnerability to Genetic and Environmental Insults in Schizophrenia. Biological Psychiatry 2022, 92: 480-490. PMID: 35305820, PMCID: PMC9372235, DOI: 10.1016/j.biopsych.2022.02.003.Peer-Reviewed Original ResearchConceptsEnvironmental insultsMore superficial layersDorsolateral prefrontal cortexPrimate dlPFCInflammatory mechanismsInflammatory insultKynurenic acidNMDA receptorsReceptor neurotransmissionDendritic spinesLayer IIICAMP/PKAGlutamatergic synapsePrefrontal cortexInsultPotassium channelsNeurotransmissionCalcium signalingSynapsesGenetic insultsSuperficial layersSchizophreniaSpineCortexNeuromodulation
2021
Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes
Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress 2021, 5: 24705470211029254. PMID: 34485797, PMCID: PMC8408896, DOI: 10.1177/24705470211029254.Peer-Reviewed Original ResearchLoss of spinesPrefrontal cortexSpine lossPersistent firingUncontrollable stressDendritic spine lossChronic stress exposureMarked cognitive impairmentInternal calcium releaseRecurrent excitatory connectionsCatecholamine releaseInflammatory signalingSynaptic connectivityCognitive disordersChronic exposureCalcium homeostasisPFC neuronsCognitive impairmentBrain regionsChronic stressCalcium releaseExcitatory connectionsStress exposurePotassium channelsSpine