2024
Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders
Datta D, Yang S, Joyce M, Woo E, McCarroll S, Gonzalez-Burgos G, Perone I, Uchendu S, Ling E, Goldman M, Berretta S, Murray J, Morozov Y, Arellano J, Duque A, Rakic P, O’Dell R, van Dyck C, Lewis D, Wang M, Krienen F, Arnsten A. Key Roles of CACNA1C/Cav1.2 and CALB1/Calbindin in Prefrontal Neurons Altered in Cognitive Disorders. JAMA Psychiatry 2024, 81: 870-881. PMID: 38776078, PMCID: PMC11112502, DOI: 10.1001/jamapsychiatry.2024.1112.Peer-Reviewed Original ResearchDorsolateral prefrontal cortexPrefrontal cortexLayer III pyramidal cellsWorking memoryCognitive disordersNeuronal firingPrimate dorsolateral prefrontal cortexPyramidal cellsSpatial working memoryWorking memory performanceRisk of mental disordersCalcium-related proteinsReduced neuronal firingL-type calcium channel Cav1.2GluN2B-NMDA receptorsL-type calcium channel activityPrefrontal neuronsL-type calcium channel blockerMemory performanceL-type calcium channelsMental disordersRisk of cognitive disordersCognitive behaviorProtein expressionAssociated with increased risk
2021
Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance
Datta D, Leslie SN, Woo E, Amancharla N, Elmansy A, Lepe M, Mecca AP, Slusher BS, Nairn AC, Arnsten AFT. Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance. Frontiers In Aging Neuroscience 2021, 13: 760270. PMID: 34867287, PMCID: PMC8634091, DOI: 10.3389/fnagi.2021.760270.Peer-Reviewed Original ResearchCognitive disordersRat medial PFCMedial PFCGCPII inhibitorsPFC cognitive deficitsPrefrontal cortical activationGlutamate carboxypeptidase IIGCPII proteinMGluR3 expressionLocal infusionSystemic administrationAged ratsGCPII inhibitionMemory performancePrefrontal cortex impairsCortical activationCognitive impairmentCognitive deficitsInflammationGenetic insultsCarboxypeptidase IIDisordersGCPIICurrent studyInhibitorsChronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes
Woo E, Sansing LH, Arnsten AFT, Datta D. Chronic Stress Weakens Connectivity in the Prefrontal Cortex: Architectural and Molecular Changes. Chronic Stress 2021, 5: 24705470211029254. PMID: 34485797, PMCID: PMC8408896, DOI: 10.1177/24705470211029254.Peer-Reviewed Original ResearchLoss of spinesPrefrontal cortexSpine lossPersistent firingUncontrollable stressDendritic spine lossChronic stress exposureMarked cognitive impairmentInternal calcium releaseRecurrent excitatory connectionsCatecholamine releaseInflammatory signalingSynaptic connectivityCognitive disordersChronic exposureCalcium homeostasisPFC neuronsCognitive impairmentBrain regionsChronic stressCalcium releaseExcitatory connectionsStress exposurePotassium channelsSpine