2003
Recognition of microbial infection by Toll-like receptors
Kopp E, Medzhitov R. Recognition of microbial infection by Toll-like receptors. Current Opinion In Immunology 2003, 15: 396-401. PMID: 12900270, DOI: 10.1016/s0952-7915(03)00080-3.Peer-Reviewed Original Research
2000
Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*
Wadleigh D, Reddy S, Kopp E, Ghosh S, Herschman H. Transcriptional Activation of the Cyclooxygenase-2 Gene in Endotoxin-treated RAW 264.7 Macrophages*. Journal Of Biological Chemistry 2000, 275: 6259-6266. PMID: 10692422, DOI: 10.1074/jbc.275.9.6259.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsCCAAT-Enhancer-Binding ProteinsCyclic AMPCyclooxygenase 2DNA-Binding ProteinsDrosophila ProteinsEndotoxinsGenes, ReporterI-kappa B ProteinsIsoenzymesJNK Mitogen-Activated Protein KinasesLipopolysaccharidesMacrophagesMAP Kinase Kinase Kinase 1MiceMitogen-Activated Protein KinasesMutationNuclear ProteinsPhosphorylationPromoter Regions, GeneticProstaglandin-Endoperoxide SynthasesProtein Serine-Threonine KinasesProteinsProto-Oncogene Proteins c-junSignal TransductionTranscriptional ActivationConceptsTranscriptional activationCis-acting transcriptional regulatory elementsReporter activityRas-independent pathwayTranscriptional regulatory elementsCis-acting elementsDominant-negative formDominant-negative expression vectorCyclic AMP response elementC-Jun phosphorylationElement-binding proteinAMP response elementImmediate early genesRAW 264.7 macrophagesTranscription factorsRaf-1E-boxRegulatory elementsAlpha mutantsCOX-2 promoterGene expressionCOX-2 reporterExpression vectorCyclic AMP response element-binding proteinC-Jun
1999
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes & Development 1999, 13: 2059-2071. PMID: 10465784, PMCID: PMC316957, DOI: 10.1101/gad.13.16.2059.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAmino Acid SequenceAnimalsBiological EvolutionCell Line, TransformedCloning, MolecularDrosophilaDrosophila ProteinsEnzyme ActivationHumansInsect ProteinsMAP Kinase Kinase Kinase 1Membrane GlycoproteinsMiceMolecular Sequence DataNF-kappa BProtein Processing, Post-TranslationalProtein Serine-Threonine KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Saccharomyces cerevisiaeSignal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsThe Toll-receptor family and control of innate immunity
Kopp E, Medzhitov R. The Toll-receptor family and control of innate immunity. Current Opinion In Immunology 1999, 11: 13-18. PMID: 10047546, DOI: 10.1016/s0952-7915(99)80003-x.Peer-Reviewed Original ResearchConceptsInducible immune response genesToll receptor familyToll receptorTransduction pathwaysImmune response genesHost defense systemInnate immune recognitionMicrobial pathogensGermline-encoded receptorsNuclear factor-kappaBMolecular patternsDefense systemInnate immunityFactor-kappaBImmune recognitionPathwayReceptorsInsectsMammalsGenesPlantsPathogensExpressionKappaBFamily
1998
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S, Janeway C. MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways. Molecular Cell 1998, 2: 253-258. PMID: 9734363, DOI: 10.1016/s1097-2765(00)80136-7.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAntigens, DifferentiationDrosophilaDrosophila ProteinsHumansInterleukin-1 Receptor-Associated KinasesMembrane GlycoproteinsMembrane ProteinsMyeloid Differentiation Factor 88NF-kappa BProtein KinasesProteinsReceptors, Cell SurfaceReceptors, ImmunologicReceptors, Interleukin-1Signal TransductionTNF Receptor-Associated Factor 6Toll-Like ReceptorsTranscription Factor AP-1ConceptsIL-1R familyNF-kappaB activationNF-kappaB pathwayImmune response genesToll/IL-1R familyAP-1 activationImmune responseIL-1RTRAF6 proteinInnate immunityNF-kappaBMyD88Drosophila Toll proteinReceptor familyToll receptorAdaptor proteinSignaling pathwaysReceptorsActivationToll proteinRegulator moleculesResponse genesAdult DrosophilaPathwayProteinNF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh S, May M, Kopp E. NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses. Annual Review Of Immunology 1998, 16: 225-260. PMID: 9597130, DOI: 10.1146/annurev.immunol.16.1.225.Peer-Reviewed Original ResearchConceptsNF-kappa BNF-kappa B/IGeneration of knockoutTranscription factor NF-kappa BFactor NF-kappa BAnti-apoptotic proteinsConserved mediatorInducible phosphorylationRel proteinsB proteinB familyOrganism's responseCell deathNormal developmentProteinNF-kappaB actB complexRecent findingsAdhesion moleculesNumerous cytokinesKinaseDiscoveryPhosphorylationCytosol