2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens
Liu E, Zhang B, Martin V, Anthonypillai J, Kraft M, Grishin A, Grishina G, Catanzaro J, Chinthrajah S, Sindher T, Manohar M, Quake A, Nadeau K, Burks A, Kim E, Kulis M, Henning A, Jones S, Leung D, Sicherer S, Wood R, Yuan Q, Shreffler W, Sampson H, Shabanova V, Eisenbarth S. Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens. Science Translational Medicine 2022, 14: eabq0599. PMID: 36383680, PMCID: PMC10219469, DOI: 10.1126/scitranslmed.abq0599.Peer-Reviewed Original ResearchConceptsPeanut allergyFood allergyEpitope specificityPredominant antibody isotypePeanut-specific IgEDifferent epitope specificitiesSimilar epitope specificityAtopic childrenEgg allergyOral toleranceAllergic infantsImmune exclusionEgg toleranceAntibody isotypesImmunoglobulin ACommensal floraSeparate cohortAllergyEgg allergensInfant stoolHealthy adultsIgAProtective roleOlder childrenChildren
2021
Wheat oral immunotherapy
Leeds S, Liu EG, Nowak-Wegrzyn A. Wheat oral immunotherapy. Current Opinion In Allergy And Clinical Immunology 2021, 21: 269-277. PMID: 33840798, DOI: 10.1097/aci.0000000000000743.Peer-Reviewed Original ResearchConceptsWheat oral immunotherapyOral immunotherapyMaintenance dosesSevere reactionsFood allergy epidemiologyLow maintenance dosesNonrandomized clinical trialRisk of reactionSustained unresponsivenessSuccessful desensitizationAdjunct therapeuticsFood allergyTrial protocolClinical trialsAllergic reactionsAllergy epidemiologyHuman trialsSafety outcomesHead comparisonAugmenting factorSmall sample sizeTrialsFood modificationImmunotherapyDosesThe role of immunoglobulin A in oral tolerance and food allergy
Pier J, Liu EG, Eisenbarth S, Järvinen KM. The role of immunoglobulin A in oral tolerance and food allergy. Annals Of Allergy Asthma & Immunology 2021, 126: 467-468. PMID: 33548469, PMCID: PMC8102345, DOI: 10.1016/j.anai.2021.01.028.Peer-Reviewed Original ResearchAntigen-Presenting Cells in Food Tolerance and Allergy
Liu EG, Yin X, Swaminathan A, Eisenbarth SC. Antigen-Presenting Cells in Food Tolerance and Allergy. Frontiers In Immunology 2021, 11: 616020. PMID: 33488627, PMCID: PMC7821622, DOI: 10.3389/fimmu.2020.616020.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsDendritic cellsOral toleranceFood allergyT cellsDifferent antigen-presenting cellsB cell antibody responseLife-threatening anaphylaxisT cell responsesImmunoglobulin E antibodiesVariety of symptomsAPC subsetsFood antigensFood toleranceAntibody responseE antibodiesAntigen presentationImmune responseMouse modelFood allergensAllergyInitial primingCell responsesPatient samplesAntigen
2020
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization
Zhang B, Liu E, Gertie JA, Joseph J, Xu L, Pinker EY, Waizman DA, Catanzaro J, Hamza KH, Lahl K, Gowthaman U, Eisenbarth SC. Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization. Science Immunology 2020, 5 PMID: 32385053, PMCID: PMC8518330, DOI: 10.1126/sciimmunol.aay2754.Peer-Reviewed Original ResearchConceptsFood antigensIgE productionIgA productionFollicular helper cellsMinority of miceHelper cell requirementDominant antibody isotypeCross-reactive IgAFollicular regulatoryDietary antigensAllergic sensitizationTolerogenic responsesMucosal adjuvantMucosal IgAHelper cellsAntibody isotypesStool samplesImmunoglobulin AT cellsFood exposureGerminal centersFood allergensAntibody productionIgADietary exposure