2024
The association between salivary oxytocin, age, and puberty in children with and without OCD
Mora-Jensen A, Clemmensen L, Grønberg M, Lebowitz E, Quintana D, Jørgensen N, Larsen C, Bak L, Christensen G, Pretzmann L, Uhre V, Christensen S, Uhre C, Korsbjerg N, Thoustrup C, Hagstrøm J, Ritter M, Plessen K, Pagsberg A, Lønfeldt N. The association between salivary oxytocin, age, and puberty in children with and without OCD. Scientific Reports 2024, 14: 28693. PMID: 39562644, PMCID: PMC11576962, DOI: 10.1038/s41598-024-80194-8.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOxytocin concentrationsPediatric obsessive-compulsive disorderSalivary oxytocin concentrationsVisual inspection of plotsOxytocin systemPsychiatric disordersSalivary oxytocinEnzyme-linked immunosorbent assayBehavioral changesPubertal stageAdolescentsModerate supportOxytocinInconsistent resultsPost-hocDisordersChildrenPost hoc testSystem activityCovariates ageParentsAssociationImmunosorbent assayHypothesis
2020
Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study
Lønfeldt NN, Strandberg-Larsen K, Verhulst FC, Plessen KJ, Lebowitz ER. Birth with Synthetic Oxytocin and Risk of Childhood Emotional Disorders: A Danish Population-based Study. Journal Of Affective Disorders 2020, 274: 112-117. PMID: 32469793, DOI: 10.1016/j.jad.2020.04.067.Peer-Reviewed Original ResearchMeSH KeywordsChildCohort StudiesDenmarkFemaleHumansOxytocinPregnancyProportional Hazards ModelsRegistriesConceptsChildhood emotional disordersSynthetic oxytocinNationwide register-based cohort studyDanish Medical Birth RegisterRegister-based cohort studyDanish population-based studyEmotional disordersSelective serotonin reuptake inhibitorsMedical Birth RegisterSerotonin reuptake inhibitorsPopulation-based studyUse of oxytocinRevision of guidelinesCrude Cox modelPrescription RegistryTraumatic Stress DisorderCohort studyLabor inductionReuptake inhibitorsDanish patientsSmoking statusObsessive-compulsive disorderBirth RegisterMaternal historyCox model
2018
Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis
Lønfeldt NN, Verhulst FC, Strandberg-Larsen K, Plessen KJ, Lebowitz ER. Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis. Psychological Medicine 2018, 49: 881-890. PMID: 30444210, DOI: 10.1017/s0033291718003021.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderPooled risk estimatesCognitive impairmentRisk estimatesNewcastle-Ottawa Quality Assessment ScaleNarrative summaryQuality Assessment ScaleNeurodevelopment of childrenUse of oxytocinAutism spectrum disorderEnglish-language studiesQuality of studiesIndependent risk estimatesOxytocin exposureLabor inductionObstetric guidelinesObservational studyNeurodevelopmental problemsPsychiatric symptomsDate restrictionsCurrent evidenceSystematic reviewAssessment ScaleAvailable evidenceHyperactivity disorderNegative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth
Lebowitz ER, Blumberg HP, Silverman WK. Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth. Journal Of Affective Disorders 2018, 245: 806-811. PMID: 30699863, PMCID: PMC6361537, DOI: 10.1016/j.jad.2018.11.070.Peer-Reviewed Original ResearchConceptsNegative peer interactionsPeer social interactionSalivary oxytocin levelsAnxious youthPeer interactionsHigher oxytocin levelsAnxiety disordersOxytocin levelsSocial interactionSuicidal ideationSocial eventsSelf-report measuresPrimary anxiety disorderSemi-structured diagnostic interviewNegative social interactionsPeripheral oxytocin levelsSample of childrenPeer victimization
2017
Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior
Lebowitz ER, Silverman WK, Martino AM, Zagoory‐Sharon O, Feldman R, Leckman JF. Oxytocin response to youth–mother interactions in clinically anxious youth is associated with separation anxiety and dyadic behavior. Depression And Anxiety 2017, 34: 127-136. PMID: 28052452, PMCID: PMC5503301, DOI: 10.1002/da.22585.Peer-Reviewed Original ResearchConceptsSeparation anxiety disorderAnxious youthAnxiety disordersSeparation anxietySalivary oxytocinAffective touchDSM-5 anxiety disordersYouth anxiety symptomsOT responseParticular anxiety disordersAttachment figuresReliable codersMaternal sensitivityDyadic behaviorsChildren's ratingsMaternal intrusivenessAttachment behaviorAnxiety symptomsAnxiety regulationSocial supportPossible intervention strategiesSignificant distressHigher youthYouthIntervention strategies
2016
Cross-generational influences on childhood anxiety disorders: pathways and mechanisms
Lebowitz ER, Leckman JF, Silverman WK, Feldman R. Cross-generational influences on childhood anxiety disorders: pathways and mechanisms. Journal Of Neural Transmission 2016, 123: 1053-1067. PMID: 27145763, PMCID: PMC5007197, DOI: 10.1007/s00702-016-1565-y.Peer-Reviewed Original ResearchConceptsAnxiety disordersChild anxiety treatment outcomeChild anxiety disordersChildhood anxiety disordersParent-based interventionsAnxiety treatment outcomesCross-generational influencesSocial referencingFamily accommodationChild anxietyParenting stylesVicarious learningOxytocinergic systemChildren's symptomsBehavioral systemsParental responsesParental anxietyMaternal anxietyAnxietyExistence of linksSevere distressDisordersPrenatal environmentTreatment outcomesResearch
2015
Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation
Lebowitz ER, Leckman JF, Feldman R, Zagoory-Sharon O, McDonald N, Silverman WK. Salivary oxytocin in clinically anxious youth: Associations with separation anxiety and family accommodation. Psychoneuroendocrinology 2015, 65: 35-43. PMID: 26716876, PMCID: PMC4895196, DOI: 10.1016/j.psyneuen.2015.12.007.Peer-Reviewed Original ResearchConceptsSalivary OT levelsFamily accommodationSeparation anxiety disorderYouth anxietyAnxiety disordersAnxious youthInterpersonal behaviorSeparation anxietyOT levelsDSM-5 anxiety disordersSeparation anxiety symptomsTreatment of anxietyNeuropeptide oxytocinSalivary OTClinical anxietyMaternal ratingsSalivary oxytocinAnxiety symptomsOxytocinergic systemRegulation of anxietyAnxious behaviorOwn behaviorAnxiety assessmentAnxietyParental involvement