2024
Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety
Kitt E, Zacharek S, Odriozola P, Nardini C, Hommel G, Martino A, Anderson T, Spencer H, Broussard A, Dean J, Marin C, Silverman W, Lebowitz E, Gee D. Responding to threat: Associations between neural reactivity to and behavioral avoidance of threat in pediatric anxiety. Journal Of Affective Disorders 2024, 351: 818-826. PMID: 38290579, PMCID: PMC10981528, DOI: 10.1016/j.jad.2024.01.204.Peer-Reviewed Original ResearchConceptsReactivity to threatMeasures of avoidanceVentral anterior insulaClinician-based measuresNeural reactivityPediatric anxietyAnxiety disordersBehavioral avoidanceFunctional magnetic resonance imaging taskAmygdala functional connectivityVentromedial prefrontal cortexTreatment-seeking sampleAvoidance of threatClinically significant constructsAssociated with tasksGeneralizability of findingsPrefrontal cortexAnterior insulaNeural findingsLaboratory tasksFunctional connectivityAnxietyAmygdalaAvoidanceSignificant constructs
2023
Assessing Anxiety-Related Impairment in Children and Adolescents
Etkin R, Lebowitz E, Silverman W. Assessing Anxiety-Related Impairment in Children and Adolescents. Assessment 2023, 31: 94-109. PMID: 37840296, DOI: 10.1177/10731911231194972.Peer-Reviewed Original ResearchDoes Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships?
Etkin R, Juel E, Lebowitz E, Silverman W. Does Cognitive-Behavioral Therapy for Youth Anxiety Disorders Improve Social Functioning and Peer Relationships? Clinical Child And Family Psychology Review 2023, 26: 1052-1076. PMID: 37838627, DOI: 10.1007/s10567-023-00454-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCognitive behavioral therapyAdolescent anxiety disordersPeer relationshipsSocial functioningAnxiety disordersYouth anxiety disordersPeer outcomesAnxiety reductionTreatment-specific effectsFunctioningTreatment specificitySystematic narrative reviewRelated difficultiesSample characteristicsMajority of studiesSpecific outcomesChildrenTreatment outcomesStatistical findingsStudy sampleDisordersNarrative reviewFindingsRelationshipAnxietyAffective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task
Nook E, Nardini C, Zacharek S, Hommel G, Spencer H, Martino A, Morra A, Flores S, Anderson T, Marin C, Silverman W, Lebowitz E, Gee D. Affective Language Spreads Between Anxious Children and Their Mothers During a Challenging Puzzle Task. Emotion 2023, 23: 1513-1521. PMID: 36595385, PMCID: PMC10314965, DOI: 10.1037/emo0001203.Peer-Reviewed Original ResearchConceptsNegative affect wordsChallenging puzzle taskAffect wordsAffective languagePuzzle taskEffective emotion regulationSpread of emotionsEmotion regulationNeuroscientific levelAnxious childrenEmotional influencesWord useBidirectional influenceAnxiety disordersBidirectional relationsMother's directionsMental healthEmotionsFuture researchWordsCurrent studyLanguageChildrenTaskMothersParent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome
Cabrera V, Buitron V, Patriarca G, Rey Y, Lebowitz E, Silverman W, Pettit J. Parent Accommodation Contemporaneously Mediates the Association Between Youth Irritability and Youth Anxiety Treatment Outcome. Behavior Therapy 2023, 54: 852-862. PMID: 37597962, PMCID: PMC10440415, DOI: 10.1016/j.beth.2023.03.002.Peer-Reviewed Original ResearchConceptsYouth anxiety severityParent accommodationCognitive-behavioral treatmentYouth irritabilityAnxiety treatment outcomesAnxiety severityChild anxietyPrimary anxiety disorder diagnosisAnxiety disorder diagnosisAnxious youthYouth anxietyYouth ages 6Adolescent irritabilityAnxiety outcomesBehavioral treatmentAnxiety protocolAnxietyGreater impairmentDisorder diagnosisAge 6Treatment outcomesFuture researchPosttreatmentIrritabilityResearch documentsMaternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels
Lebowitz E, Marin C, Orbach M, Salmaso N, Vaccarino F, Silverman W. Maternal FGF2 levels associated with child anxiety and depression symptoms through child FGF2 levels. Journal Of Affective Disorders 2023, 326: 193-197. PMID: 36717031, PMCID: PMC10104478, DOI: 10.1016/j.jad.2023.01.090.Peer-Reviewed Original ResearchConceptsFGF2 levelsDepressive symptomsDepression symptomsChild anxietySymptoms of anxietyRatings of anxietyGrowth factor 2Maternal anxietySymptomsDepressed childrenDepressionChild depressionMothersChildrenFactor 2Self-report ratingsAnxietyIntergenerational pathwaysNon-referred childrenRange of anxietyFGF2AssociationLevelsMaternal
2022
Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth
Pettit J, Rey Y, Marin C, Bechor M, Lebowitz E, Vasey M, Jaccard J, Abend R, Pine D, Bar-Haim Y, Silverman W. Attention Training as a Low-Intensity Treatment for Concerning Anxiety in Clinic-Referred Youth. Behavior Therapy 2022, 54: 77-90. PMID: 36608979, PMCID: PMC9825787, DOI: 10.1016/j.beth.2022.07.004.Peer-Reviewed Original ResearchConceptsAttention Bias Modification TreatmentAttention control trainingAttention trainingAnxiety severityAttention controlAnxiety levelsAttention biasNeutral facesLow-intensity treatmentGlobal impairmentDot-probe taskYouth anxiety severityClinic-Referred YouthFull criteriaAttention focusingControl trainingTreatment researchYouthIndependent evaluatorsTrainingImpairment ratingsACT trialsPosttreatmentSeverity ratingsRatings
2020
Using Evaluative Criteria to Review Youth Anxiety Measures, Part I: Self-Report
Etkin RG, Shimshoni Y, Lebowitz ER, Silverman WK. Using Evaluative Criteria to Review Youth Anxiety Measures, Part I: Self-Report. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 58-76. PMID: 32915074, PMCID: PMC7914129, DOI: 10.1080/15374416.2020.1802736.Peer-Reviewed Original ResearchConceptsSelf-report measuresYouth self-report measuresYouth Anxiety MeasureEvidence-based treatment deliveryPsychological scienceAnxiety measuresSelf-ReportEvidence-based assessmentPsychometric propertiesEvaluative reviewMost ratingsEvaluative criteriaEvidence-based updateFuture directionsRatingsMeasuresEvidence baseTreatment deliveryAnxietyHigh confidenceAssessment functionDisordersConfidenceAbnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder
Zhang Y, Liu W, Lebowitz ER, Zhang F, Hu Y, Liu Z, Yang H, Wu J, Wang Y, Silverman WK, Yang Z, Cheng W. Abnormal asymmetry of thalamic volume moderates stress from parents and anxiety symptoms in children and adolescents with social anxiety disorder. Neuropharmacology 2020, 180: 108301. PMID: 32910952, DOI: 10.1016/j.neuropharm.2020.108301.Peer-Reviewed Original ResearchConceptsThalamic volumeThalamic asymmetryAge group differencesAbnormal asymmetryAnxiety disordersBilateral thalamic volumeAnxiety symptomsBrain developmental abnormalitiesOlder age groupsSocial anxiety disorderChronic family stressMedication-free childrenFunctional lateralizationMental disordersAge groupsChronic stressBrain developmentTotal SCARED scoresDisordersFamilial stressChildrenAnxiety severityAdolescentsEmotional disordersDevelopmental abnormalitiesA computational network perspective on pediatric anxiety symptoms
Abend R, Bajaj MA, Coppersmith DDL, Kircanski K, Haller SP, Cardinale EM, Salum GA, Wiers RW, Salemink E, Pettit JW, Pérez-Edgar K, Lebowitz ER, Silverman WK, Bar-Haim Y, Brotman MA, Leibenluft E, Fried EI, Pine DS. A computational network perspective on pediatric anxiety symptoms. Psychological Medicine 2020, 51: 1752-1762. PMID: 32787994, PMCID: PMC8486314, DOI: 10.1017/s0033291720000501.Peer-Reviewed Original ResearchParent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment
Zilcha-Mano S, Shimshoni Y, Silverman WK, Lebowitz ER. Parent-Child Agreement on Family Accommodation Differentially Predicts Outcomes of Child-Based and Parent-Based Child Anxiety Treatment. Journal Of Clinical Child & Adolescent Psychology 2020, 50: 427-439. PMID: 32401557, PMCID: PMC8496486, DOI: 10.1080/15374416.2020.1756300.Peer-Reviewed Original ResearchConceptsParent-child agreementFamily accommodationMultilevel response-surface analysisAnxious Childhood EmotionsChild anxiety treatmentChild anxiety severityCognitive behavioral therapyAnxiety symptom severityDistinct underlying mechanismsChildhood EmotionsChildhood anxietySupportive parentingAnxiety treatmentParent reportBehavioral therapyRole of accommodationAnxiety severityAnxiety disordersPoor treatment outcomesTreatment outcomesSymptom severitySubsequent treatment outcomesTreatment endSignificant predictorsChildren
2019
Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety?
Shimshoni Y, Lebowitz ER, Brotman MA, Pine DS, Leibenluft E, Silverman WK. Anxious-Irritable Children: A Distinct Subtype of Childhood Anxiety? Behavior Therapy 2019, 51: 211-222. PMID: 32138933, PMCID: PMC7080292, DOI: 10.1016/j.beth.2019.06.005.Peer-Reviewed Original ResearchParent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions
Lebowitz ER, Marin C, Martino A, Shimshoni Y, Silverman WK. Parent-Based Treatment as Efficacious as Cognitive-Behavioral Therapy for Childhood Anxiety: A Randomized Noninferiority Study of Supportive Parenting for Anxious Childhood Emotions. Journal Of The American Academy Of Child & Adolescent Psychiatry 2019, 59: 362-372. PMID: 30851397, PMCID: PMC6732048, DOI: 10.1016/j.jaac.2019.02.014.Peer-Reviewed Original ResearchConceptsParent-based treatmentAnxious Childhood EmotionsChildhood anxiety disordersFamily accommodationChildhood anxietyAnxiety disordersChildhood EmotionsSupportive parentingParenting stressAnxiety outcomesCognitive behavioral therapyPrimary anxiety disorderParent interventionBehavioral therapyChildren's ratingsAnxiety severityTreatment credibilityClinician-rated scalesParent treatmentParent involvementAnxietyDiagnostic InterviewEmotionsParentingIndependent evaluatorsFamily accommodation mediates nightmares and sleep-related problems in anxious children
Lebowitz ER, Shimshoni Y, Silverman WK. Family accommodation mediates nightmares and sleep-related problems in anxious children. Journal Of Anxiety Disorders 2019, 62: 94-99. PMID: 30660831, PMCID: PMC6432767, DOI: 10.1016/j.janxdis.2019.01.004.Peer-Reviewed Original ResearchConceptsSleep-related problemsAnxious childrenFamily accommodationHypothesized mediational pathwaysStructural equation modelingStructural equation modelChildhood anxietyMediational pathwaysFirst empirical evidenceMaternal reportsEquation modelingFit indicesNightmaresEquation modelChildrenEmpirical evidenceEmpirical dataAnxietyAccommodationParticipants
2018
Implications of the Research Domain Criteria project for childhood anxiety and its disorders
Lebowitz ER, Gee DG, Pine DS, Silverman WK. Implications of the Research Domain Criteria project for childhood anxiety and its disorders. Clinical Psychology Review 2018, 64: 99-109. PMID: 29526524, PMCID: PMC6668617, DOI: 10.1016/j.cpr.2018.01.005.Peer-Reviewed Original ResearchConceptsChildhood anxiety disordersChildhood anxietyResearch Domain Criteria projectAnxiety disordersSocial processesMental Health's Research Domain Criteria projectNegative Valence Systems domainFronto-amygdala circuitryThreat learningPsychiatric disordersNegative valencePediatric anxietyChildren's fearsDevelopmental psychopathologyPrevalent psychiatric disordersParticular social processesAnxietyAttachment processRDoCResearch linksFearYouthTranslational approachDisordersInterdisciplinary approach
2017
Maternal Acceptance Moderates Fear Ratings and Avoidance Behavior in Children
Shimshoni Y, Silverman WK, Byrne SP, Lebowitz ER. Maternal Acceptance Moderates Fear Ratings and Avoidance Behavior in Children. Child Psychiatry & Human Development 2017, 49: 460-467. PMID: 29188403, PMCID: PMC5871552, DOI: 10.1007/s10578-017-0765-5.Peer-Reviewed Original ResearchConceptsChildren’s avoidance behaviorMaternal acceptanceAvoidance behaviorBehavioral avoidanceAnxiety disordersFear of spidersSelf-rated fearLevel of avoidanceSpider stimuliAnxious childrenChild avoidanceChildren's fearsChildren's feelingsFearAvoidanceChildrenHallmark featureMothersAcceptanceDisordersAdolescentsBehaviorStimuliFeelingsModeratesAnxiety Sensitivity Moderates the Relation Between Family Accommodation and Anxiety Symptom Severity in Clinically Anxious Children
Schleider JL, Lebowitz ER, Silverman WK. Anxiety Sensitivity Moderates the Relation Between Family Accommodation and Anxiety Symptom Severity in Clinically Anxious Children. Child Psychiatry & Human Development 2017, 49: 187-196. PMID: 28616690, PMCID: PMC6688181, DOI: 10.1007/s10578-017-0740-1.Peer-Reviewed Original ResearchConceptsAnxiety symptom severityChild anxiety symptom severityFamily accommodationAnxiety sensitivityAnxious childrenSymptom severityClinically Anxious ChildrenAnxiety-provoking stimuliLong-term anxietySubset of childrenAnxiety severityImmediate distressMothers' ratingsChildren's symptomsParental involvementChildrenDistressRatingsSeverity associationStrength of associationAnxietyHigh levelsStimuliAccommodationLinkSocial Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder
van Schalkwyk GI, Marin CE, Ortiz M, Rolison M, Qayyum Z, McPartland JC, Lebowitz ER, Volkmar FR, Silverman WK. Social Media Use, Friendship Quality, and the Moderating Role of Anxiety in Adolescents with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2017, 47: 2805-2813. PMID: 28616856, PMCID: PMC6688174, DOI: 10.1007/s10803-017-3201-6.Peer-Reviewed Original ResearchConceptsFriendship qualityAnxiety levelsSocial media useHigher friendship qualityComplex social informationAutism spectrum disorderMedia useSpectrum disorderSocial informationModerating RoleSocial mediaSocial engagementASDOffline social activitiesAnxietyAdolescentsSignificant anxietyComparison controlsSocial activities
2015
Anxiety sensitivity moderates behavioral avoidance in anxious youth
Lebowitz ER, Shic F, Campbell D, Basile K, Silverman WK. Anxiety sensitivity moderates behavioral avoidance in anxious youth. Behaviour Research And Therapy 2015, 74: 11-17. PMID: 26348546, PMCID: PMC4895193, DOI: 10.1016/j.brat.2015.08.009.Peer-Reviewed Original ResearchConceptsAnxiety sensitivityFear of spidersSensations of anxietyBehavioral avoidanceSpider stimuliAnxious youthRole of ASAvoidant behaviorAnxiety treatmentOverall avoidanceAnxietyStimuliYouthFearStrongest predictorAvoidancePatient's abilityIndividualsSensationModeratesAbilityImplicationsPredictorsSupportBehaviorFamily accommodation mediates the association between anxiety symptoms in mothers and children
Jones JD, Lebowitz ER, Marin CE, Stark KD. Family accommodation mediates the association between anxiety symptoms in mothers and children. Journal Of Child And Adolescent Mental Health 2015, 27: 41-51. PMID: 25958796, DOI: 10.2989/17280583.2015.1007866.Peer-Reviewed Original ResearchConceptsFamily accommodationChild anxietyStructural equation modellingAnxiety symptomsMaternal anxietySubclinical anxiety symptomsPediatric anxiety disordersDevelopment of interventionsChild avoidMothers of childrenMediational roleGreater symptom severityAnxiety disordersOwn anxietyMaternal accommodationAnxietyEquation modellingPoor treatment outcomesSymptom severityParentsChildrenTreatment outcomesAccommodationYouthMothers