2020
How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues
Blanc-Potard AB, Groisman EA. How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues. Trends In Microbiology 2020, 29: 98-106. PMID: 32807623, PMCID: PMC7855738, DOI: 10.1016/j.tim.2020.07.003.Peer-Reviewed Original ResearchConceptsNutritional immunityHost cell compartmentsAbundant divalent cationHost tissuesSalmonella enterica serovar TyphimuriumAvailability of nutrientsPathogen responseEnterica serovar TyphimuriumMacrophage proteinHost organismLiving cellsMagnesium limitationAmino acidsIntracellular pathogensSerovar TyphimuriumNutrient concentrationsCell compartmentPathogensDivalent cationsNutrientsMagnesium deprivationEssentialityOrganismsCytoplasmProtein
2017
Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation
May J, Rasmussen D, Davie T, Vaneerd C, Groisman E, Bhattacharyya B. Structural and Biochemical Characterization of a Periplasmic Lipoprotein with a Role in Adaptation of Salmonella to Magnesium Limitation. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.761.11.Peer-Reviewed Original ResearchPeriplasmic lipoproteinMagnesium limitationAtomic-resolution structural dataFamily of proteinsFundamental biochemical processesBeta-sheet secondary structureAdaptation of SalmonellaGenetic screenCircular dichroism spectroscopyBacterial adaptationLocalization sequenceSalmonella proteinsBiochemical approachesIon homeostasisBacterial virulenceProtein monomersBiochemical characterizationCertain pathogenic bacteriaMolecular mechanismsMonomeric molecular weightUnknown functionPhysiological functionsLiving cellsSecondary structureDichroism spectroscopy